Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening conditions associated with significant morbidity and mortality. They are considered to be part of a spectrum of cutaneous drug reactions, differing only by their extent of skin detachment due to keratinocyte apoptosis. Drugs are assumed as the main cause of Stevens-Johnson syndrome and toxic epidermal necrolysis in mos...

© 2014 Nirmala et al.; licensee El Mednifico Journal. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cite this article as: Nirmala SVSG, Dadeepya R, Lalitha V, Sivakumar N...

Background: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis comprise a spectrum of severe hypersensitivity skin reactions. is the least on mucosal erosions, with being most severe. Syndrome/Toxic disease keratinocytes therefore any squamous cell epithelium at risk. This includes cornea, conjunctiva, oral mucosa, esophagus, urethra, anal canal. reaction typically drug-induced has very po...

BACKGROUND Recently, human herpesvirus 6 (HHV-6) reactivation has been frequently observed in patients with drug-induced hypersensitivity syndrome or drug rash with eosinophilia and systemic symptoms but not in patients with other types of drug eruptions, eg, Stevens-Johnson syndrome and toxic epidermal necrolysis (TEN). This finding suggests that there is a close relationship between HHV-6 rea...

Physicians writing prescriptions for their patients must warn them about possible side effects. One such potential complication of drugs—including tetracycline—is Stevens-Johnson syndrome, a potentially fatal condition that manifests mainly on the skin and mucosal surfaces but also affects other vital organs. Many types of therapy have proved efficacious for treating the syndrome, but use of st...

The Stevens-Johnson syndrome (SJS) is a rare immune-complex-mediated hypersensitivity disorder which affects 7 cases per million persons per year. This article describes a case study of a 22 year old male patient who was admitted to the Sheth Vadilal Sarabhai General Hospital, Ahmedabad, with chief complaints of congestion of eyes with mucosal involvement included erythema, edema, sloughing, bl...