We gave atropine intravenously to autonomically decentralized, open-chest, anesthetized dogs and stimulated the discrete intracardiac sympathetic nerve fibers to the sinoatrial (SA) (SAS stimulation) or atrioventricular (AV (AVS stimulation) nodal region. A brief burst of neural stimuli was delivered during each cardiac cycle. SAS stimulation consistently decreased the atrial cycle length but h...

We gave atropine intravenously to autonomically decentralized, open-chest, anesthetized dogs and stimulated the discrete intracardiac sympathetic nerve fibers to the sinoatrial (SA) (SAS stimulation) or atrioventricular (AV) (AVS stimulation) nodal region. A brief burst of neural stimuli was delivered during each cardiac cycle. SAS stimulation consistently decreased the atrial cycle length but ...

Microelectrode Arrays In article number 2201716 by Matthew W. Kay, Luyao Lu, and co-workers, a microelectrode array (MEA) is laminated on the heart to show its stretchability. Another stretched MEA placed in light path capability for co-localized optical mapping. Green represents stimulation light. Yellow red lights represent resulting calcium voltage fluorescence while blue electrical signals ...

The decrease of psychophysical detection thresholds as a function of pulse rate for a fixed-duration electrical pulse train is referred to as multipulse integration (MPI). The MPI slopes correlate with anatomical and physiological indices of cochlear health in guinea pigs with cochlear implants. The aim of the current study was to assess whether the MPI slopes were related to the spatial spread...

Interaction of the elongation factor EF-Tu with the antibiotic kirromycin results in activation of the GTPase center of the factor and in induction of an additional tRNA binding site (tRNA binding site II to distinguish it from the classical tRNA binding site I). Activation of the GTPase center under these conditions is stimulated by addition of tRNA. Two-fold evidence is presented that this st...

Functional implications of across-site variation in detection thresholds in subjects with cochlear implants were evaluated by comparing thresholds to speech recognition performance. Detection thresholds for bipolar (BP) and monopolar (MP) stimulation of all available stimulation sites were assessed in 21 subjects with Nucleus CI24M and CI24R(CS) implants. We found significant negative correlati...