This study focuses on the preventive effects of aqueous extract of Cichorium intybus (CIE) on streptozotocin (STZ) induced β-cell damage. Pancreatic β-cells or islet were treated with STZ in presence and absence of Cichorium intybus and the inhibitory effect of it against STZ toxicity were determined in RINm5F (RIN) rat insulinoma cells. Cell viability, Nitric oxide production and Insulin secre...

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that identified by the gradual decline in memory and cognitive function. It classified deposition of Aβ plaques, build-up intracellular neurofibrillary tangle neuron loss. Neurotrophic factors play critical role treatment disease. However, utilization such neurotrophins has encountered certain difficulties side effects. Novel ...

Aim: The aim of this study is to determine resveratrol effects on sarcopenic obesity in C57BL/6J mice skeletal muscle due type 2 diabetes mellitus-induced the elderly. Mice (2 years old) feed a high-oil-fat diet (HFD) for weeks and then injected with streptozotocin (STZ, 30mg/kg) induce mellitus continued HFD fed 7 become obese sarcopenia. High- (200 mg/kg), middle- (150 low-dose (50mg/kg) was ...

To study the effect of okra aqueous extract on intestinal flora diabetic rats. Taking normal SD rats as CK group, induced by 40 mg/(kg•bw) streptozotocin (STZ) intraperitoneally M and gavaged with 500 were CKO MO groups,respectively. The bacterial cecum contents was analyzed 16S rRNA V3-V4 sequencing after 8 weeks experiment. Compared CK, increased Firmicutes 14.00% decreased Proteobacteria 19....

The impact of estrogen on brain function, especially in individuals with diabetes, remains uncertain. This study aims to compare cerebral glucose metabolism levels intact rats, ovariectomized (OVX) and 17β-estradiol (E2)-treated OVX diabetic female rats. Sixteen rats were administered a single intraperitoneal injection 70 mg/kg streptozotocin (STZ) induce diabetes (intact, n = 6; OVX, OVX+E2-tr...

Amongst the numerous co-adjuvant therapies which could influence the incidence and progression of diabetic complications, antioxidants and flavonoids are currently being tested in clinical trials. We investigated the effect of naringerin on biochemical parameters in streptozotocin-induced (STZ 60 mg/kg, i.p.) diabetic rats. Male rats were divided into four groups: G1: untreated controls; G2: no...

The present paper aims to evaluate antihyperglycemic activity of methanol extract of Citrus limetta fruit peel (MECL) in streptozotocin-induced (STZ; 65 mg/kg b.w.) diabetic rats. Three days after STZ induction, diabetic rats received MECL orally at 200 and 400 mg kg(-1) body weight daily for 15 days. Glibenclamide (0.5 mg kg(-1) p. o.) was used as reference drug. Blood glucose levels were meas...

Folium mori, the leaves of Morus alba L., has traditionally been used for the treatment of diabetic hyperglycemia. It has been shown to induce enhanced NOS expression in the hypothalamus of rats with streptozotocin (STZ)-induced diabetes. In the present study, the effect of Folium mori on the expression of nitric oxide synthase (NOS) in the hypothalamus of STZ-induced diabetic rats was investig...

Because we found that WTC rats might be resistant to streptozotocin (STZ), we have elucidated the mechanisms of resistant to the diabetogenic effects of STZ in the WTC rats. Dose response to STZ was evaluated with glucose levels. No significant changes in glucose level to STZ administration were observed in WTC rats. Insulin secretion by suppling glucose was preserved in WTC rats even after STZ...

Insulin resistance and loss of β-cell mass cause Type 2 diabetes (T2D). The objective of this study was to generate a nongenetic mouse model of T2D. Ninety-six 6-month-old C57BL/6N males were assigned to 1 of 12 groups including (1) low-fat diet (LFD; low-fat control; LFC), (2) LFD with 1 i.p. 40 mg/kg BW streptozotocin (STZ) injection, (3), (4), (5), (6) LFD with 2, 3, 4, or 5 STZ injections o...