psoriasis and pemphigus vulgaris are two inflammatory and autoimmune diseases. their concomitant occurrence in one patient is very rare. we describe a 57-year-old patient with a history of severe plaque type psoriasis for 2 years. after a few months, he presented with disseminated bullae and mucosal erosions which were documented as pemphigus vulgaris. both of the diseases were successfully con...

The endoplasmic reticulum (ER) is the site of synthesis and maturation of proteins designed for secretion or for localization on the cell membrane. Various types of stress from both inside and outside cells disturb ER function, thus causing unfolded or misfolded proteins to accumulate in the ER. To improve and maintain the ER functions against such stresses, the ER stress response pathway is ac...

as a safeguard program that limits the proliferative capacity of cells when exposed to endogenous or exogenous stress signals [1, 2]. However, the senescence phenotype is also considered as a sign that the life span of a cell has reached its end. Indeed, in the early 1960s, Hayflick and Moorhead showed that despite the maintenance of optimal culturing conditions for a long period of time, norma...

Many physical diseases have been reported to be associated with psychosocial factors. In these diseases, assessment relies mainly on subjective symptoms in natural settings. Therefore, it is important to assess symptoms and/or relationships between psychosocial factors and symptoms in natural settings. Symptoms are usually assessed by self-report when patients visit their doctors. However, self...

Free radicals (FRs) generation is an unavoidable consequence of the life in an oxygen-rich atmosphere. FRs can be considered a double-edged sword. Beneficial effects of FRs occur at moderate concentrations and involve physiological roles in cellular responses to noxia, as in defense against infectious agents, in the function of a number of cellular signaling pathways and the induction of a mito...

UNLABELLED Nitric oxide (NO) is involved in stress physiology and stress-related disease processes. Like stress, NO seems to be capable of principally exerting either beneficial or deleterious effects. The actual distinction depends on a multitude of factors. Moreover, NO counteracts norepinephrine (NE) activity and sympathetic responsivity. Thus, NO and the stress (patho)physiology are closely...

Flos Lonicerae is one of the oldest and most commonly prescribed herbs in Eastern traditional medicine to treat various inflammatory diseases. In the present study, we investigated the effects of ethyl acetate fraction of Flos Lonicerae (GC-7101) on experimental gastric ulcer models and its mechanisms of action in gastric ulcer healing. The pharmacological activity of GC-7101 was investigated i...