Abstract African swine fever virus (ASFV) is an important pathogen causing acute infectious disease in domestic pigs and wild boars that seriously endangers the global industry. As ASFV structurally complex encodes a large number of functional proteins, no effective vaccine has been developed to date. Thus, dissecting mechanisms immune escape induced by proteins crucial. A previous study showed...

The enhanced microdialysis relative recovery (RR) of some hydrophobic tricyclic drugs (imipramine, desipramine, amitriptyline, carbamazepine and promethazine) is discussed. Enhanced RR was achieved by including a binding agent [beta-cyclodextrin (beta-CD) or 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD)] in the microdialysis perfusion fluid to form inclusion complexes with the drugs, which inc...

We have investigated the dynamics between free fibronectin receptors and clusters of them organized into adhesion plaques on CHO cells using the ability of these free integrins to be endocytosed and recycled to the plasma membrane. Indirect inhibition of the endocytic cycle by monensin resulted in the subsequent internalization of free receptors, which we followed by indirect immunostaining and...

autoimmunity and viral infections are closely associated fields, and viruses have been proposed as a likely aetiological, contributory or triggering factors of systemic autoimmune diseases. hepatitis c virus seems to be the virus usually associated with the appearance of autoimmune diseases, and the relationship between chronic hepatitis c virus infection and some autoimmune disease has been st...

treatment of severe immune thrombocytopenic purpura (itp) accompanied by life-threatening bleeding events is challenging and a combination of treatment measures should be undertaken to rapidly increase the platelet count. herein, we report a case of severe itp in a seven-year-old boy who suffered from massive bleeding which was totally unresponsive to conventional therapeutic interventions. sin...

magnetite (fe3o4) nanoparticles have been successfully prepared by a novel one-step and surfactant-free approach utilizing ferrous ion, as a single iron source. in this manner, the reaction occurs between two aqueous solutions via the spontaneous transfer of ammonia gas from one to another in room temperature. no ferric source or oxidizing specie, oxidation controlling and capping agents are ne...

Macromolecular interactions are formed between proteins, DNA and RNA molecules. Being a principle building block in macromolecular assemblies and pathways, the interactions underlie most of cellular functions. Malfunctioning of macromolecular interactions is also linked to a number of diseases. Structural knowledge of the macromolecular interaction allows one to understand the interaction's mec...

A simple, efficient, and eco-friendly protocol for the N-Boc protection of the amine moiety in a variety of compounds with di-tert-butyl dicarbonate under water-acetone catalyst-free conditions is described. The corresponding monocarbamate is obtained in excellent yields on short reaction times. No competitive side reactions such as isocyanate urea and O-Boc were observed. This method represent...

Copyright © 2000, Idea Group Publishing. Robert Putnam (1993) has developed a theory of social capital to explain the effect of decreasing community participation and civic engagement on declining institutional performance. Subsequently, there has been much speculation as to whether emerging virtual communities can counteract this trend. We apply the findings of computer-mediated communication ...

P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a phenomenon in which cells become resistant to structurally and mechanistically unrelated drugs resulting low intracellular drug concentrations. It one of the noteworthy problems malignant tumor clinical therapeutics. So P-gp protein ideal targets solve MDR. Based on lead compound 5m obtained from our previous work, series furan deri...