IT is known that bacteriostatic concentrations of streptomycin can be produced in various tissues of the rabbit's eye after systemic administration (Leopold and Nichols, 1946) ; after application to the conjunctival sac when the cornea is inflamed or abraded, but not otherwise (Id, ibid., and Bellows, Burkholder, and Farmer, 1947); after intravitreous injection; and, rather transiently, after s...

PURPOSE To investigate the efficacy and safety of cationic nano-copolymers CS-g-(PEI-b-mPEG) mediated IκB kinase beta (IKKβ) targeting siRNA in modulating wound healing in a monkey model of glaucoma filtration surgery. METHODS The IKKβ targeting siRNAs were chemically synthesized and screened in cultured monkey Tenon's fibroblasts in vitro. Fourteen monkeys underwent trabeculectomy and were r...

PURPOSE We report a case of herpetic epithelial keratitis that developed after subconjunctival triamcinolone acetonide injection (STI). METHODS A 65-year-old female with anterior uveitis and hypotony in her right eye was given a STI (2 mg/0.5 ml). After the injection, she developed redness and an ocular discharge. A clinical examination was performed and real-time polymerase chain reaction (P...

Background: A pterygium is a fleshy, wing-shaped growth from the conjunctiva, crossing over limbus onto cornea. The tissue fibrovascular and can occur nasal or temporal It be bilateral process asymmetric with one eye affected by larger than other. Objectives: To compare between Subconjunctival injection of bevacizumab (Avastin) conjunctival autograft in treatment primary pterygium. Patients Met...

The impermeability of the blood-aqueous barrier to certain antibiotics precludes their use in intraocular infections, and it is very difficult to identify the causative organism if laboratory facilities are not available. With these limitations in view we embarked upon a blanket trial of framycetin sulphate (Soframycin eye drops o 5 per cent.) by intracameral injection in nine cases of intracta...

An improved method for experimental keratitis due to Pseudomonas aeruginosa is described. Essential features of the method are use of inbred guinea pigs, intracorneal injection of bacteria, subconjunctival injection of antibiotics, "blind" evaluation of results, and statistical analysis of data. Untreated ocular infections were most severe 5 to 7 days after infection. Sterilized bacterial suspe...