BACKGROUND The coronary circulation has been shown to remain responsive to vasodilator and vasoconstrictor stimuli during myocardial ischemia. Because serotonin possesses both vasodilator and vasoconstrictor properties, we examined its effect in the coronary circulation distal to an arterial stenosis that resulted in myocardial hypoperfusion during exercise. METHODS AND RESULTS Seven chronica...

Introduction: Delayed enhancement using segmented inversion recovery (IR) TurboFLASH imaging is the clinical gold standard for identifying myocardial infarction. It is also clinically used for assessment of non-ischemic cardiomyopathy [1]. Although this technique allows high contrast between infarct/infiltrate and normal myocardium, it is limited in its evaluation of the subendocardium because ...

1. Introduction pressure–flow relationship with a central portion running parallel to the pressure axis that is followed by a steep Essential hypertension is a main risk factor for left increase in flow at higher perfusion pressures (Fig. 2). If, ventricular hypertrophy (LVH), ischemic heart disease and however, coronary vessels are maximally dilated then such hypertensive cardiomyopathy [1]. I...

especially if one does not fail to notice the often associated decrease in T-wrave voltage in leads I and avL which are often present in these cases. I am in complete disagreement, however, with the interpretation of myocardial repolarization with refer¬ ence to T-wave inversion as given by Dr. Nikolic, and stated as representing the opinion of most cardiologists. His assumption regarding both ...

BACKGROUND The present study was performed to define the mechanisms underlying spontaneously occurring ventricular arrhythmias in the failing heart. METHODS AND RESULTS Three-dimensional cardiac mapping from as many as 232 intramural sites was performed in five dogs with ischemic cardiomyopathy induced by multiple intracoronary embolizations. After 5 to 10 weekly embolizations with 90-microns...

Increased heart rate and left ventricular pressure during humoral and neuronal adrenergic activation act to restrict blood flow preferentially in the subendocardium. The hypothesis was advanced that alpha-adrenergic coronary vasoconstriction preferentially in the subepicardium may counterbalance the enhanced extravascular compression in the subendocardium and serve to maintain blood flow transm...

BACKGROUND Undersized mitral annuloplasty, widely used for ischemic and functional mitral regurgitation (MR), has been proposed as an "annular solution to a ventricular problem." Beyond relief of MR, it is thought to improve global left ventricular (LV) shape, hence potentially reducing myocardial stress and promoting beneficial reverse LV remodeling. We previously observed that undersized annu...

Positron emission tomography (PET) plays an important role in the assessment of myocardial blood flow (MBF). Absolute quantification of MBF is feasible using tracer kinetic models. The most common method for quantifying MBF involves the acquisition of dynamic images with the cyclotron-produced radiopharmaceuticals N-ammonia and O-water. An alternative method is the use of the generator produced...

Objective: To describe the MRI abnormalities observed in acute myocarditis. Materials and Methods: Retrospective cross-sectional study with a descriptive aim, carried out at North Franche-Comte Hospital, over period of 12 months, from January 2021 to December 2021. It covered all patients who received an heart disease were diagnosed The diagnosis myocarditis was retained on basis two arguments:...