BACKGROUND Radial artery spasm is a common hinderance during transradial approaches for neuroangiography. Ways of alleviation have been described, including patient sedation, local lidocaine, or even prophylactic administration intra‐arterial vasodilators. METHODS We present case wedged catheter attributable to radial spasm, which failed all conventional methods relieve spasm. RESULTS The was u...

Background: We sought to compare the effectiveness and safety of sublingual versus vaginal misoprostol for the termination of pregnancy with a live full-term fetus.Methods: This randomized, triple-blind, placebo-controlled clinical trial was performed on 200 primiparous women with normal, singleton, full-term pregnancies candidated for the induction of labor. Sublingual and vaginal tablets cont...

The demand for sublingual tablets has been growing during the previous decades especially for drugs with extensive hepatic first-pass metabolism. Vinpocetine, a widely used neurotropic agent, has low oral bioavailability due to its poor aqueous solubility and marked first-pass metabolism. Accordingly, the aim of this work was to develop tablets for the sublingual delivery of vinpocetine. Initia...

Glutathione (GSH) is critical to fight against oxidative stress. Its very low bioavailability limits the interest of a supplementation. The purpose of this study was to compare the bioavailability, the effect on oxidative stress markers and the safety of a new sublingual form of GSH with two commonly used dietary supplements, N-acetylcysteine (NAC) and oral GSH. The study was a three-week rando...

Background: The idea of this study was to evaluate the efficacy and safety different routes administration misoprostol - 50µg oral, 25µg vaginal sublingual for induction labour in women with premature rupture membranes after 34 weeks gestation.Design: Randomized controlled trial.Sample: A total 252 gestation indications labour.Methods: Study conducted from 01/02/2022 31/11/2022, Women admitted ...

OBJECTIVE Dexrazoxane is an antioxidant prodrug that on hydrolysis is converted into an intracellular iron chelator. We hypothesized that the antioxidant effects of dexrazoxane would prevent homocysteine-induced endothelial dysfunction in the brachial artery of normal human subjects. METHODS AND RESULTS Ten healthy volunteers completed a randomized, double-blind, crossover study. Plasma homoc...

OBJECTIVE To explore what triggers an elevated body temperature of > or =40.0 degrees C in some women given misoprostol, a prostaglandin E1 analogue, for postpartum haemorrhage (PPH). DESIGN Post hoc analysis. SETTING One tertiary-level hospital in Quito, Ecuador. POPULATION A cohort of 58 women with a fever of above 40 degrees C following treatment with sublingual misoprostol (800 microg...

Nifedipine is frequently used for patients who require an immediate reduction of blood pressure elevated temporarily by various administration techniques including sublingual route without administrating intravenous infusion of vasodilator. A cross-over clinical study was conducted to investigate the optimal administration method of nifedipine for rapid management of hypertension. Four method o...