Abstract Achieving sufficient worldwide vaccination coverage against SARS-CoV-2 will require additional approaches to currently approved viral vector and mRNA vaccines. Subunit vaccines may have distinct advantages when immunizing vulnerable individuals, children pregnant women. Here, we present a new generation of subunit targeting antigens CD40-expressing antigen-presenting cells. We demonstr...

Thrombocytopoiesis is a complex process beginning at the level of hematopoietic stem cells, which ultimately generate megakaryocytes, large marrow cells with distinctive morphology, and then, through terminal maturation, megakaryocytes shed thousands platelets into circulation. This controlled by intrinsic extrinsic factors. Emerging data indicate that an important control on late stages thromb...

Chimeric cDNAs encoding a sarcoplasmiclendoplasmic reticulum Ca-ATPase (SERCA1) and regions of the Na,K-ATPase a-subunit were constructed to seek the minimal region of the a-subunit sufficient for assembly with the Na,K-ATPase @-subunit. cDNAs encoding a chimera and the chicken @-subunit were coexpressed in mammalian cells and assembly was assayed by immune precipitation of the chimeric subunit...

Subunit I of chloroplast ATP synthase is reviewed until now to be equivalent to subunit b of Escherichia coli ATP synthase, whereas subunit II is suggested to be an additional subunit in photosynthetic ATP synthases lacking a counterpart in E. coli. After publication of some sequences of subunits II a revision of this assignment is necessary. Based on the analysis of 51 amino acid sequences of ...

Although the catalytic (C) subunit of cAMP-dependent protein kinase is N-myristylated, it is a soluble protein, and no physiological role has been identified for its myristyl moiety. To determine whether the interaction of the two regulatory (R) subunit isoforms (R(I) and R(II)) with the N-myristylated C subunit affects its ability to target membranes, the effect of N-myristylation and the R(I)...

Global population growth and rising health concerns have highlighted the importance of developing effective vaccination strategies, subunit vaccines hold great promise for meeting market demand. Compared to traditional whole-cell vaccines, contain only a part infectious microorganism induce an immune response against main pathogen.