Lexmaulová L., R. Novotná, P. Raušer, A. Nečas: Complications Related to Surgical Treatment of Intervertebral Disc Disease in Dogs. Acta Vet. Brno 2008, 77: 269-276. After intervertebral disk surgery we often have to deal with various complications (seizures, gastrointestinal tract (GIT) ulcerations, cystitis, and surgical wound healing problems). These complications may lead to the death of th...

We tested the hypothesis that changes in arterial blood flow modify the function of endothelial Ca -activated K channels [calcium-activated K channel (KCa), small-conductance calciumactivated K channel (SK3), and intermediate calcium-activated K channel (IK1)] before arterial structural remodeling. In rats, mesenteric arteries were exposed to increased [ 90%, high flow (HF)] or reduced blood fl...

Protein farnesylation is a form of posttranslational modification that occurs in most, if not all, eukaryotic cells. Inhibitors of protein farnesyltransferase (PFTIs) have been developed as anticancer chemotherapeutic agents. Using the knowledge gained from the development of PFTIs for the treatment of cancer, researchers are currently investigating the use of PFTIs for the treatment of eukaryo...