We tested the hypothesis that 5-aminosalicylic acid (5-ASA) inhibits toxin A-induced generation of colonic leukotriene B4 (LTB4) and toxin A colitis in rats. Isolated colonic segments in anesthetized rats were treated intraluminally with toxin A for 3 hours with or without 30 minutes of pretreatment with either 5-ASA or sulfapyridine and then colonic tissue levels of LTB4 were measured and infl...

The title mixed-ligand copper(I) complex, [Cu(C(18)H(13)N(4)O(5)S)(C(18)H(15)P)(2)], was synthesized via solvothermal reaction of [Cu(PPh(3))(2)(MeCN)(2)]ClO(4) and sulfasalazine [systematic name: 2-hydr-oxy-5-(2-{4-[(2-pyridylamino)sulfon-yl]phen-yl}diazen-yl)benzoic acid]. The mononuclear complex displays a trigonal coordination geometry for the Cu(I) atom, which is surrounded by two P-atom d...

OBJECTIVE The aim of this paper is to report the first case of drug-induced eosinophilic myocarditis (EM) in a patient with hereditary periodic fever syndrome (PFS). CASE A 28-year-old man with hyper-IgD syndrome, one of the PFS, developed a sulfasalazine-induced systemic hypersensitivity reaction complicated by EM. Thirteen days after sulfasalazine introduction, which had been given for arth...

Feeding states may affect the performance of colonic prodrugs. The aim is to investigate the influence of feeding regimen in Wistar rats on: (i) distribution and pH contents along the gut and (ii) metabolism of two colonic prodrugs, diclofenac-β-cyclodextrin and a commercially available control, sulfasalazine, within the caecal and colonic contents. Male Wistar rats were subject to four differe...

An 18-month-old male entire golden retriever presented with inappetence and a 12-hour history of episodic vomiting. The dog had been receiving sulfasalazine 15 mg/kg twice daily for one year the treatment lymphoplasmacytic colitis, which was well controlled prior to presentation. no other drug or toxin exposure. Investigations initially revealed raised liver enzymes, increased during hospitalis...

Drought causes an increase in some gene expression in plant tissues such as plasma membrane intrinsic proteins type 1 (PIP1), 9-cis-epoxycarotenoid dioxygenase (NCED) SlAREB1. The effects of exogenous abscisic acid (ABA) and two sulfonamide compounds, namely, sulfacetamide (Sa) and sulfasalazine (SS) were studied on gene expression of tomato (Lycopersicon esculentum Mill. Cv. Super chief) under...