Three novel eunicellin-based diterpenoids, namely klysimplexin sulfoxides A-C (1-3), were isolated from the cultured soft coral Klyxum simplex. Their structures were elucidated by spectroscopic methods, particularly 1D and 2D-NMR experiments. Compounds 1-3 significantly inhibited the accumulation of the pro-inflammatory iNOS protein in LPS-stimulated RAW264.7 macrophage cells. Compound 3 also s...

A flavin-dependent group E monooxygenase ("GEM”) has been characterized by crystal-structure analysis, computational and kinetic studies to reveal substrate binding mechanistic details for this class of enzymes the first time. Based on these data, Dirk Tischler, Norbert Sträter, co-workers redesigned pocket synthesize chiral epoxides sulfoxides with high stereoselectivity, a true treasure molec...

A biotin-degrading particulate system has been obtained by sonic rupture of a soil pseudomonad which grows on d-biotin as sole source of carbon, nitrogen, and sulfur. Investigation of the catabolism of l*C-biotin and its sulfoxides in this system has revealed the following. Degradation of biotin to CO2 is enhanced in the bufferwashed particulate preparations by addition of adenosine triphosphat...

1-Butyl-3-methylimidazolium bromide ([bmim]Br) as an ionic liquid promoted selectively oxidation of aliphatic and aromatic sulfides to the corresponding sulfoxides and the oxidative coupling of thiols to disulfides by NaBrO3 in excellent yields under neutral conditions.

Zn/AcOH on silica gel converts a range of structurally different sulfoxides to their corresponding thioethers in excellent yields under microwave irradiation. It has been found that chemoselective deoxygenation of sufoxides can be achieved in the presence of other reducible functional groups such as acetals, acids, amides,   esters, ketones and nitriles.  

Thiols (RSH) or thiolates (RS) are one of the most popular anchor groups used for attaching molecules to gold electrodes in molecular junction devices. Operation of these devices under oxidizing conditions may lead to oxidation of the thiolate anchor groups. Herein we investigate the plausibility of this process as a potential source of current fluctuation. Density functional theory calculation...

The separation of 17 chiral sulfoxides and eight chiral sulfinate esters by gas chromatography (GC) on four derivatized cyclodextrin chiral stationary phases (CSPs) (Chiraldex G-TA, G-BP, G-PN, B-DM) is presented. Many of these compounds are structural isomers or part of a homologous series. Differences in enantioselectivity of the methyl phenyl sulfoxide isomers on the derivatized gamma cyclod...

In addition to halide oxidation, the vanadium haloperoxidases are capable of oxidizing sulfides to sulfoxides. Four vanadium complexes with tripodal amine ligands, K[VO(O(2))(heida)] (1), VO(2)(bpg) (2), K[VO(2)(ada)] (3), and K(2)[VO(O(2))(nta)] (4), previously shown to perform bromide oxidation (Colpas, G. J.; Hamstra, B. J.; Kampf, J. W.; Pecoraro, V. L. J. Am. Chem. Soc. 1996, 118, 3469-347...

Cellulose sulfuric acid as a bio-polymer based solid catalyst efficiently catalyzes the selectively oxidation of sulfides to sulfoxides and thiols to disulfides using hydrogen peroxide as a green oxidant with good yields at room temperature. The developed method offers a number of advantages such as high selectivity, mild reaction conditions, simple operation, cleaner reaction profiles, low...