The ATP-sensitive K+ channel (KAT, channel), a particular class of K + channel inhibited by intracellular ATP, was first described in cardiac muscle [ 11 and has subsequently been found in pancreatic B-cells [2], skeletal muscle [3], smooth muscle [4] and central neurons [ 5 ] . There is considerable evidence that this channel plays an essential role in the regulation of insulin secretion from ...

Madam, Diabetes mellitus (DM) is the most common metabolic disease worldwide. A quarter of Pakistan’s adult population affected by DM. In Pakistan, popular mono-therapy for treating both pre-diabetic and diabetic patients metformin. For Metformin combined with exogenous insulin/sitagliptin/sulphonylureas dual therapy.1 Multiple studies over past decade have shown encouraging results GLP-1 analo...