The paramagnetic molecule nitric oxide (NO), produced from L-arginine by a specific enzyme (NO synthase), has been shown to be involved in a surprising variety of mammalian cellular responses, including the regulation of T cell immunity to alloantigens in vitro. In cytotoxic activated macrophages, NO production results in a characteristic pattern of alteration of iron-containing enzyme function...

In the present study, Fe3O4 super paramagnetic nanoparticles were synthesized via co-precipitation of Fe3+ and Fe2+ chloride salts in the presence of ammonia Solution. The product was characterized by Fourier Transform Infrared spectroscopy (FT-IR), Transmission Electron Microscopy (TEM), and zeta–potential particle size distributing methods. The synt...

Introduction Magnetic resonance imaging is a powerful tool for visualizing cellular/macrophage tracking and migration or inflammatory processes. MRI examinations can be performed longitudinally and non-invasively, at isotropic image resolutions approaching 50 microns within reasonable scan times in live animals. Whereas vascular and interstitial compartments are investigated using Gadolinium-ba...

Experimental allergic encephalomyelitis (EAE) is a demyelinating autoimmune disorder that can be induced in susceptible mice by T lymphocytes sensitized to central nervous system (CNS) myelin components and is a prime animal model for the human CNS demyelinating disorder, multiple sclerosis (MS). Although CNS inflammation in which T lymphocytes and activated macrophages are the predominant cell...