Supersaturated lipid-based drug delivery systems are increasingly being explored as a bio-enabling formulation approach, particularly in preclinical evaluation of poorlywater-soluble drugs. While increasing the load through thermally-induced supersaturation resulted enhanced vivo exposure for some drugs, others, such cinnarizine, supersaturated have not been found beneficial to increase bioavai...

An automatic system for growing crystals from seeded supersaturated solutions at constant supersaturation is described. Control of burettes and data acquisition are controlled by computer. The system was tested with a study of the calcium oxalate kinetics of crystal growth.

Abstract On Mars, condensation is the major factor constraining vertical distribution of water vapor. Recent measurements and temperature profiles showed that can be strongly supersaturated at above level where clouds form during aphelion perihelion seasons. Since 2018, near‐infrared spectrometer (NIR) Atmospheric Chemistry Suite onboard Trace Gas Orbiter has measured H 2 O using solar occultat...

In this paper, an analytical method of solving the integro-differential system kinetic and balance equations describing evolution ensemble crystals during intermediate phase bulk crystallization process is described. The theory developed for first- second order corresponding to absence presence fluctuations in particle growth rates. crystal-size distribution function as well dynamics metastabil...

Supersaturated designs are very cost-effective with respect to the number of runs and as such highly desirable in many preliminary studies industrial experimentation. Variable selection plays an important role analyzing data from supersaturated designs. Traditional approaches, best subset variable stepwise regression, may not be appropriate this sit- uation. In paper, we introduce a procedure s...

This study focuses on the difference in microstructural features and physical properties of Al-2Fe Al-4Fe alloys subjected to large plastic straining. The intermetallic particle morphology initial state is shown be a key parameter influencing grain fragmentation process and, as result, these two alloys. We demonstrate that shape average size Al-Fe particles provide stronger effect microstructur...

The initial oxidation stages of copper and copper-iron alloys have been studied by the AtomProbe Field Ion Microscope (AP-FIM). The depth profiles of copper oxide formed in-situ were successfully determined. The composition of the oxide was close to the value of Cu20, but a large concentration fluctuation was found. The interface between the oxide and the metal was found to be diffuse, the widt...