نتایج جستجو برای: suppressive function

تعداد نتایج: 1223809  

Journal: :Journal of immunology 2007
Jamie G Evans Karina A Chavez-Rueda Ayad Eddaoudi Almut Meyer-Bahlburg David J Rawlings Michael R Ehrenstein Claudia Mauri

The immune system contains natural regulatory cells important in the maintenance of tolerance. Although this suppressive function is usually attributed to CD4 regulatory T cells, recent reports have revealed an immunoregulatory role for IL-10-producing B cells in the context of several autoimmune diseases including collagen-induced arthritis. In the present study, we attribute this suppressive ...

Journal: :Frontiers in immunology 2016
Jacobo López-Abente Rafael Correa-Rocha Marjorie Pion

Regulatory T cells (Tregs) play an important role in infections, by modulating host immune responses and avoiding the overreactive immunity that in the case of human immunodeficiency virus (HIV) infection leads to a marked erosion and deregulation of the entire immune system. Therefore, the suppressive function of Treg in HIV-infected patients is critical because of their implication on prevent...

2016
Cameron R. Cunningham Ameya Champhekar Michael V. Tullius Barbara Jane Dillon Anjie Zhen Justin Rafael de la Fuente Jonathan Herskovitz Heidi Elsaesser Laura M. Snell Elizabeth B. Wilson Juan Carlos de la Torre Scott G. Kitchen Marcus A. Horwitz Steven J. Bensinger Stephen T. Smale David G. Brooks P'ng Loke

Persistent viral infections are simultaneously associated with chronic inflammation and highly potent immunosuppressive programs mediated by IL-10 and PDL1 that attenuate antiviral T cell responses. Inhibiting these suppressive signals enhances T cell function to control persistent infection; yet, the underlying signals and mechanisms that program immunosuppressive cell fates and functions are ...

Journal: :Annual review of cancer biology 2021

Advances in immunotherapy have underscored the importance of antitumor immune responses controlling cancer. However, tumor microenvironment (TME) imposes several obstacles to proper function cells, including a metabolically challenging and immunosuppressive microenvironment. The increased metabolic activity cells can lead depletion key nutrients required by accumulation byproducts that hamper i...

Journal: :Journal of immunology 2008
Yong Zheng Claire N Manzotti Fiona Burke Laure Dussably Omar Qureshi Lucy S K Walker David M Sansom

The role of CTLA-4 in regulatory T cell (Treg) function is not well understood. We have examined the role of CTLA-4 and its relationship with the transcription factor FoxP3 using a model of Treg induction in human peripheral blood. Activation of human CD4(+)CD25(-) T cells resulted in the appearance of a de novo population of FoxP3-expressing cells within 48 h. These cells expressed high levels...

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