An experimental system to explore central tolerance in humans is unavailable. However, the human endogenous retrovirus K-18 (HERV-K18) region on chromosome 1 provides an excellent model: HERV-K18 encodes a superantigen (SAg) stimulating Vbeta7CD4 T cells that is implicated in type 1 diabetes and Epstein-Barr virus persistence. In this study, we have addressed thymic HERV-K18 SAg expression, the...

The gas permeability of equilibrium foam films stabilized with an alpha-olefin sulfonate surfactant was measured. The permeability coefficient, K (cm/s), was obtained as a function of the electrolyte (NaCl) concentration, surfactant concentration, and temperature. The addition of salt to the film-forming solution leads to a decrease of the film thickness, which was complemented by an increase o...

Previously, through a proteomic analysis, proliferating cell nuclear antigen (PCNA) was found to be overexpressed in the sodium antimony gluconate (SAG)-resistant clinical isolate compared to that in the SAG-sensitive clinical isolate of Leishmania donovani. The present study was designed to explore the potential role of the PCNA protein in SAG resistance in L. donovani. For this purpose, the p...

There is a growing body of evidence over the last years suggesting continuous positive airway pressure (CPAP) ventilation being the first choice of ventilatory support in newborns with extremely low gestational age, and early rescue surfactant treatment being as effective as prophylactic therapy. The Intubation Surfactant Extubation procedure is discussed as an alternative procedure that may ha...

Inhalation injury is one of the main causes of death in patients with severe burns. Administration of exogenous surfactant appears promising for the treatment of acute respiratory failure. We report our clinical experience with this approach. A 35 yr-old man was admitted to our burns unit after an industrial accident. He had sustained a 60% total body surface area full-thickness burn combined w...

Photovoltaic systems have been increasingly used in the generation of electrical energy because of the cost of energy produced from fossil fuels is rising day to-day and there by photovoltaic energy becomes a promising alternative source for fossil fuels. Power quality is the major problem that occurs between grid to end user transmission lines. DSTATCOM is the one of the power quality compensa...

in this research, the efficiency of the comminution circuit as well as the efficiency of size classification equipment of the concentrator plant 2 of sarcheshmeh copper complex was studied. the comminution circuit of this plant includes one sag mill in a closed circuit with a vibrating screen and one ball mill with a size classification system of hydrocyclone. the goal of this work was to calcu...

We studied surfactant synthesis and turnover in vivo in preterm infants using the stable isotope [U-13C]glucose, as a precursor for the synthesis of palmitic acid in surfactant phosphatidylcholine (PC). Six preterm infants (birth weight, 916 +/- 244 g; gestational age, 27.7 +/- 1.7 wk) received a 24-h [U-13C]glucose infusion on the first day of life. The 13C-enrichment of palmitic acid in surfa...

We present a route for producing monodisperse micro and nanodrops that is based on a liquid-gas phase transition occurring within a microfluidic device. A gas which is soluble in water is mixed with an insoluble one and injected into an aqueous surfactant solution, using a microfluidic device that produces monodisperse bubbles. As the soluble gas diffuses out of the bubbles, they shrink and the...

We have compared three treatment strategies, that aim to prevent repetitive alveolar collapse, for their effect on gas exchange, lung mechanics, lung injury, protein transfer into the alveoli and surfactant system, in a model of acute lung injury. In adult rats, the lungs were ventilated mechanically with 100% oxygen and a PEEP of 6 cm H2O, and acute lung injury was induced by repeated lung lav...