نتایج جستجو برای: sustained release tablet
تعداد نتایج: 315031 فیلتر نتایج به سال:
The effect of once-daily atenolol, sustained-release oxprenolol (a new formulation of oxprenolol presented as a compressed tablet in a waxed matrix), and long-acting propranolol (a new formulation presented as spheriods in a capsule) was studied in a double-blind crossover trial in 23 carefully selected hypertensive outpatients. After a run-in period with matching placebo each patient received ...
OBJECTIVE DA-9601, an extract of Artemisia asiatica containing eupatilin and jaceosidin as active compounds, has been prescribed to treat gastritis in Asia. In recent times, sustained-release, floating gastroretentive (GR) tablets of DA-9601 are available on the market. In the present study, the physical properties and in vitro drug release profile, in vivo gastric residence time, and gastropro...
The aim of the work was to develop Theophylline hydrochloride sustain release tablet using Methocel k 15 MCR, Methocel K100M CR premium and Methocel K4M CR premium in blending and granulation stage of processing and evaluate their physico-chemical properties and also compared the dissolution profile with the marketed drugs.Tablets were prepared by wet granulation method. The active ingredient, ...
The study on the effect of polymer concentration in vitro drug release profile revealed that there is a change parameters (t50, t80, and MDT) with concentration. Fraction HPMC K4M, K 100 M, Ethyl Cellulose were required to be 15, 10, 7 mg respectively for designing optimized batch F7. rate Colchicine decreased proportionally an increase ethyl K100 M. Also high amount K4M leads less initial sust...
The objective of this study was to evaluate the pharmacokinetic and pharmacodynamic properties of furosemide following gastroretentive dosage from (GRDF) administration. A furosemide (60 mg) GRDF, releasing the drug during 6 hours in vitro, or an immediate-release tablet was administered to healthy male volunteers (N = 14) in a crossover design. Food and liquid intake were standardized; urine w...
Floating matrix tablets of metformin hydrochloride were developed and evaluated for increase bioavailability by increasing gastric residence time and sustained release of drug on the upper part of gastrointestinal tract thereby diminishing side effects and enhanced patient compliance. Metformin hydrochloride, an oral antidiabetic having narrow absorption window in the upper part of gastrointest...
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