A series of phosphine-ligated palladium precatalysts based on N-methyl- and N-phenyl-2-aminobiphenyl have been developed. Substitution at the nitrogen center prevents the presence of traces of aminobiphenyls that contain a free -NH2 group from contaminating cross-coupling products. These precatalysts produce N-substituted carbazoles upon activation, which cannot consume starting materials. Thes...

Tetraphenylethene (TPE) substituted phenanthroimidazoles 3a and 3b were designed and synthesized by the Suzuki cross-coupling reaction. They show reversible mechanochromic behavior with contrast colors between sky-blue and yellow green. The powder XRD studies show that destruction of a crystalline state into an amorphous state is responsible for mechanochromism. Hydrogen bonding interaction of ...

In this note, we give a precise construction ofone of the families 2-designs arose from studying ŕag-transitive with parameters(v, k, λ) whose replication numbersrare coprime to λ. We show that for given positive integer q=22n+1⩾8, there exists 2-design parameters (q2+ 1, q, q−1) and numberq 2 admitting Suzuki group Sz(q) asits automorphism group. also construct family q(q−1),(q−1)(q2−q−1)) the...

A catalyst system for the preparation of biaryls containing four ortho substituents via Suzuki coupling is described. The combination of a catalytic quantity of Pd2(dba)3 with either an electron-rich biarylphosphine or DPEPhos is effective using a wide range of substrates. The X-ray crystal structure of (dba)Pd(2-(9-phenanthryl)phenyl-dicyclohexylphosphine), in which the Pd is coordinated to th...

The title compound, C(14)H(13)NO(4), was prepared through a palladium-catalysed Suzuki-Miyaura coupling reaction. The asymmetric unit comprises two mol-ecules related by pseudo-inversion symmetry. The dihedral angles between the benzene rings in the two mol-ecules are 44.30 (6) and 48.50 (6)° while those between the benzene ring and the nitro group are 6.54 (13) and 5.73 (10)°. The crystal pack...

The regiochemical outcome of Suzuki couplings of non-symmetric dibromobenzenes is investigated. Selectivities are dependent on the proximity of the bromine atom to alkene substituents, not on steric or electronic effects. Extension to a one-pot three-component Suzuki reaction leads to efficient terphenyl syntheses.

A one-pot regioselective bis-Suzuki-Miyaura or Suzuki-Miyaura/Sonogashira reaction on 2,4-dibromo-1-methyl-5-nitro-1H-imidazole under microwave heating was developed. This method is applicable to a wide range of (hetero)arylboronic acids and terminal alkynes. Additionally, this approach provides a simple and efficient way to synthesize 2,4-disubstituted 5-nitroimidazole derivatives with antibac...

Catalytic enantiotopic-group-selective cross-couplings of achiral geminal bis(pinacolboronates) provide a route for the construction of nonracemic chiral organoboronates. In the presence of a chiral monodentate taddol-derived phosphoramidite ligand, these reactions occur with high levels of asymmetric induction. Mechanistic experiments with chiral (10)B-enriched geminal bis(boronates) suggest t...

Hisao Yamamura,* William C. Cole,* Satomi Kita, Shingo Hotta, Hidemichi Murata, Yoshiaki Suzuki, Susumu Ohya, Takahiro Iwamoto, and Yuji Imaizumi Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan; The Smooth Muscle Research Group, Department of Physiology and Pharmacology, Faculty of Medicine, University of Calga...

The leucodystrophies are a heterogeneous group of inherited neurological disorders all characterized by progressive symmetrical demyelination without any marked inflam-matory response, causing loss of motor, sensory, and intellectual functions with an eventual fatal outcome. Included in the group are metachromatic leucodystrophy (sulphatide lipidosis), Krabbe's globoid cell leucodystrophy, Cana...