BACKGROUND/AIMS Low gamma-glutamyltransferase (GGT) level was shown to be an independent predictor of a sustained virological response (SVR) in chronic hepatitis C. We aimed to determine factors associated with high GGT level, and to evaluate whether low GGT level is an independent predictor of a SVR in chronic hepatitis C genotype 1. METHODS We retrospectively reviewed our data of patients w...

XIE, Y. G., H. Y. ZHANG, H. Y. WANG, L. F. WANG and ZH. M. YUAN, 2013. Prediction of multidimensional time series based on GS-RSR-SVR and its application in agricultural economy. Bulg. J. Agric. Sci., 19: 1327-1336 This paper proposes a method that creatively applies a Geo-statistics tool (GS) to complete fast and adequate order determination and introduces a novel algorithm, named Reasonable S...

In this paper, Support Vector Regression (SVR) training models using three different kernels: polynomial, Radial Basis Function (RBF), and mixed kernels, are constructed to demonstrate the training performance of unarranged data obtained from 32 virtual 3-D computer models. The 32 samples used as input data for training the three SVR models are represented by the coordination value sets of poin...

Forecasting of gas emission rate in mine is a complicated problem due to its nonlinearity and the small quantity of training data. Support vector regression (SVR) can solve the problem with small samples, nonlinear and high dimensions. However, the precision of SVR is significantly affected by its parameter. In order to improve the mine gas emission rate accurately, an optimal selection approac...

Noninvasive electrocardiographic imaging, such as the reconstruction of myocardial transmembrane potentials (TMPs) distribution, can provide more detailed and complicated electrophysiological information than the body surface potentials (BSPs). However, the noninvasive reconstruction of the TMPs from BSPs is a typical inverse problem. In this study, this inverse ECG problem is treated as a regr...

The likelihood of a sustained virological response (SVR) is the most important factor for physicians and patients in the decision to initiate and continue therapy for chronic hepatitis C (CHC) infection. This study identified predictive factors for SVR with peginterferon plus ribavirin (RBV) in patients with CHC treated under 'real-life' conditions. The study cohort consisted of patients from a...

BACKGROUND The efficacy of re-treating genotype I hepatitis C virus (HCV) patients who failed combination therapy with interferon/pegylated interferon (PEG-IFN) and ribavirin remains unclear. AIMS To quantify sustained virological response (SVR) rates with different re-treatment regimens through meta-analysis of randomized controlled trials (RCTs). METHODS Randomized controlled trials of ge...

BACKGROUND Predictors of response of chronic hepatitis B (CHB) to lamivudine therapy need better definition. Whether hepatitis B virus (HBV) genotypes could serve as such a predictor has not been well studied. AIM To study the association of HBV genotypes with the outcome of lamivudine treatment in patients with CHB. METHODS Seventy-six patients with CHB (45 HBeAg +ve) received lamivudine 1...

Despite the gain in sustained virological responses (SVR) provided by protease inhibitors (PIs), failures still occur. The aim of this study was to determine if a baseline analysis of the NS3 region using ultradeep pyrosequencing (UDPS) can help to predict an SVR. Serum samples from 40 patients with previously nonresponding genotype 1 chronic hepatitis C who were retreated with triple therapy, ...

There are few data about the long-term histological outcome of HIV-/HCV-coinfected patients after therapy with interferon and ribavirin. We performed an observational study of 216 patients who received therapy against HCV and who had at least three successive transient elastographies (TE) during the follow-up. The primary endpoint was confirmed fibrosis regression, defined as a reduction of at ...