c NORMAL SWALLOWING Sherrington originally studied swallowing in decerebrate cats. He described the effect of various agents—whiskey, oil, water—which, when dropped onto the area supplied by the superior laryngeal nerve, would elicit a “swallow”. This “swallow” did not involve any preparation of a bolus or any lingual propulsion, and was justifiably considered to be a reflex. I will use the ter...

Johanna Savilampi (2015): Effects of remifentanil on esophageal sphincters and swallowing function, Örebro Studies in Medicine 119. Pulmonary complications like pneumonia are common perioperatively, and one potentially important cause is thought to be silent aspiration. There are several levels of defence against pulmonary aspiration that can be affected by drugs in anaesthesia. Competence of e...

Mechanical stimulation of the pharyngeal areas readily elicits reflex swallowing. However, it is much more difficult for electrical stimulation of the glossopharyngeal nerve (GPN) to evoke reflex swallowing than it is for stimulation of the superior laryngeal nerve (SLN) to do so. These paradoxical findings remain unexplained; hence, the main purpose of this study was to explain this contradict...

Swallowing movements are produced by a central pattern generator located in the medulla oblongata. It has been established on the basis of microelectrode recordings that the swallowing network includes two main groups of neurons. One group is located within the dorsal medulla and contains the generator neurons involved in triggering, shaping, and timing the sequential or rhythmic swallowing pat...

Various therapeutic approaches for dysphagia management are based on modifications of bolus properties to change swallowing biomechanics and increase swallowing safety. Limited evidence exists for the effects of carbonation and bolus temperature on swallowing behavior. Here, we investigated the effects of carbonation and temperature on swallowing behavior using a novel automated and complex swa...

Although the cerebral cortex has been implicated in the control of swallowing, the functional organization of the human cortical swallowing representation has not been fully documented. Therefore, the present study determined the cortical representation of swallowing in fourteen healthy right-handed female subjects using single-event-related functional magnetic resonance imaging (fMRI). Subject...

Human and ovine fetuses demonstrate an enhanced rate of swallowing, an activity critical for amniotic fluid regulation. Fetal swallowing may be modulated by both systemic and central factors. Nitric oxide (NO) is a central neuromodulator that has been localized to brain regions regulating thirst and swallowing. We sought to determine if NO contributes to the regulation of spontaneous ovine feta...

OBJECTIVE To compare the swallowing functions according to the lesion locations between brain tumor and stroke patients. METHODS Forty brain tumor patients and the same number of age-, lesion-, and functional status-matching stroke patients were enrolled in this study. Before beginning the swallowing therapy, swallowing function was evaluated in all subjects by videofluoroscopic swallowing st...

Objective numerical data on swallowing function are needed to aid in eating and swallowing intervention and preventive rehabilitation. Using noninvasive methods, the influences of age and differences in size of water bolus on laryngeal activity and respiratory activity were examined in healthy young and older women. Swallowing function was influenced by age and bolus size. Influence of bolus si...

We evaluated impedance pharyngography (IPG), a new method to assess swallowing function based on changes in the electrical impedance of the neck during swallowing. The electrical impedance of the neck, recorded by the 4-electrode method, changed with the equivalent cross-sectional area of the route of the electric current due to reflex activities of related organs during swallowing. IPG wavefor...