Production of MHC-I ligands from antigenic proteins generally requires multiple proteolytic events. While the proteolytic steps required for antigen processing in the endogenous pathway are clearly established, persisting gaps of knowledge regarding putative cross-presentation compartments have made it difficult to map the precise proteolytic events required for generation of cross-presented an...

An integrated manufacturing process simulation framework has been developed to predict the trimmed edge tensile stretchability of AA6111-T4 sheets by incorporating the burr geometry, damage, and plastic strain from trimming simulations into subsequent tensile stretchability simulations. The influence of the trimming die clearances on the predicted tensile stretching ductility (stretchability) i...

We present an innovative and efficient technique for post-fabrication trimming of silicon photonic integrated circuits (PICs). Our approach exploits the high photosensitivity of chalcogenide glasses (ChGs) to induce local and permanent modifications of the optical properties and spectral responses of ChG-assisted silicon devices. We experimentally demonstrate the potential of this technique on ...

Robust distances are mainly used for the purpose of detecting multivariate outliers. The precise definition of cut-off values for formal outlier testing assumes that the “good” part of the data comes from a multivariate normal population. Robust distances also provide valuable information on the units not declared to be outliers and, under mild regularity conditions, they can be used to test th...

OBJECTIVE To assess the efficacy of prophylactic hoof health examination and trimming during midlactation at reducing the incidence of lameness during late lactation in dairy cows. DESIGN Randomized field trial. ANIMALS 333 Holstein cows. PROCEDURES Cows without apparent lameness were randomly allocated into 1 of 2 groups approximately 204 days after calving. Cows allocated to the treatme...

Most of the industrial parts are designed as trimmed NURBS. Today’s graphics hardware supports the high-speed display of polygonal objects consisting of triangles. This means that analytical surfaces (like NURBS) need to be triangulated so they can be displayed by 3D graphics cards. To be able to control the quality of the tesselated model, the triangulation should be carried out with a given e...

BACKGROUND "Facing the block" is defined as trimming tissue on a microtome from peripheral or deep surgical margins before sectioning. Facing includes trimming performed intentionally but unnecessarily, accidentally, or out of necessity because of one's choice of embedding and freezing method. OBJECTIVE To assess whether facing the block is associated with a greater number of stages to clear ...

Composition, change and complexity have attracted ev- eryone’s attention towards Self-Adaptive systems. These systems, inspired by the human body, are capable of adapting to changes in the inner and outer environment. The main objective of this study is to achieve a more con- venient availability for e-banking services in the payment switch, using self-healing systems and focusing on the failur...