Joint pain accompanied by erythema, swelling, and decreased range of motion is concerning for septic arthritis and typically warrants joint aspiration. The synovial fluid white blood cell count plays a central role in the decision-making process regarding these patients. Traditional teaching holds that a cell count greater than 50,000 white blood cells/µL is likely caused by infection and there...

A joint affected with rheumatoid arthritis undergoes a number of pathological changes. The synovial membrane proliferates and begins to show round cell infiltration. Degenerative and proliferative changes are encountered in the arterioles and venules of the synovial membrane. Local necroses occur here and there in the tissue. The articular cartilage becomes thinner and spots of erosion appear i...

Iron dcxtran (molecular weight 7,000) diffuses rapidly from the joint cavity through the synovium, along lymphatics and cxtraccllular tissuc spaces; articular cartilagc is impermeable to iron dextran. Thcre is also rapid cellular uptake by synovial lining cells, particularly of the vacuolar type; cndoplasmic reticulum-containing lining cells rarely take up iron dextran. Cellular uptake is proba...

Synthesis of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) has been shown in cells from knee joint synovial fluid of 20 patients with inflammatory rheumatoid disease, reactive or psoriatic arthritis, or gout, all of which had high synovial fluid cell counts, and by cells from a patient with aseptic necrosis of a femoral condyle after short term (less than 24 hours) or long term (seven days) primary cu...

Thrombomodulin (TM) is a transmembrane glycoprotein that interacts with thrombin, thereby serving as a cofactor in the activation of protein C, a major physiologically relevant natural anticoagulant. Although initially described as a vascular endothelial cell receptor, TM has also been reported to be synthesized by several cells, including megakaryocytes, platelets, monocytes, neutrophils (PMN)...

synovial hemangioma is a rare benign malformation of the synovium. it presents frequently in the knee with pain, tenderness, intermittent swelling and recurrent hemarthrosis. mri can be helpful in diagnosis of synovial hemangioma. in this paper, we present a 45-year-old lady with chronic symptoms and obscure clinical symptoms for 35 years which finally diagnosed and managed arthroscopically as ...

OBJECTIVE To characterise the effect of interleukin-4 (IL-4) on the biosynthesis of cyclo-oxygenases I (COX I) and II (COX II), the rate limiting enzymes of the synthesis of prostaglandin E2 (PGE2), in freshly prepared rheumatoid synovial cells. METHODS Adherent synovial cells were obtained from rheumatoid synovium by collagenase digestion. The concentrations of PGE2 in culture supernatants w...

Rheumatoid arthritis is an autoimmune disease characterized as joint synovial inflammation. MicroRNA is a group of small noncoding RNA molecules discovered in recent years that can posttranscriptional regulate mRNA expression and involved in a variety processes of immune cell activation and differentiation. There is still lack of study about the role of miR-451 in rheumatoid arthritis. Synovial...

MicroRNA (miRNA) can function as tumor suppressors or oncogenes, and also as potential specific cancer biomarkers; however, there are few published studies on miRNA in synovial sarcomas, and their function remains unclear. We transfected the OncomiR miRNA Precursor Virus Library into synovial sarcoma Fuji cells followed by a colony formation assay to identify miRNAs to confer an aggressive tumo...