subcutaneous panniculitis-like t-cell lymphoma (sptcl) is an infrequent cytotoxic t-cell lymphoma of the skin with a unique immunophenotypic profile. here we describe this lymphoma in a 30-year-old iranian woman. she presented with periorbital edema, mandibular swelling with edematous areas on her face and two small lymph nodes (6-7mm) in the cervical area. histopathological findings revealed l...

Bcl-2 inhibitors are currently being evaluated in clinical studies for treatment of patients with solid tumors and hematopoietic malignancies. In this study we explored the potential for combining the pan-Bcl-2 inhibitor GX15-070 (GX15; obatoclax) with immunotherapeutic modalities. We evaluated the in vitro effects of GX15 on human T cell subsets obtained from PBMCs in terms of activation, memo...

Tumor immunotherapy has had demonstrable efficacy in patients with cancer. The most promising results have been with T-cell-based therapies. These include adoptive cell transfer of tumor-infiltrating lymphocytes, genetically engineered T cells, and immune checkpoint inhibitor antibodies. In this review, we describe the different T-cell-based strategies currently in clinical trials and put their...

Mitofusin 2 (Mfn2), a mitochondrial protein, was shown to have antiproliferative properties when overexpressed. In this article, we show that activation of resting human peripheral blood T cells caused downregulation of Mfn2 levels. This downregulation of Mfn2 was blocked by different inhibitors (mTOR inhibitor rapamycin, PI3K inhibitor LY294002, and Akt inhibitor A443654), producing cells that...

Abstract Parkinson’s Disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons and accumulation α-synuclein (α-Syn). Targeting JAK/STAT pathway to treat PD under investigation due its roles in inflammatory cytokine production activation immune cells. Striatal injection sonicated human α-Syn pre-formed fibrils (PFF) enhances cell infiltration, phosphorylation ...

The BG1 gene is a disease resistance candidate in chicken, which located the MHC region. mechanism of known as an inhibitor T lymphocyte cell activation. This study aims to identify diversity SNP IPB-D2 chicken line. for new line from cross IPB-D1 was selected high body and good productivity. A total 27 DNA samples (G0) chickens 58 (G2) were sequenced genes. found 6 point mutations (g.4489 G&gt...