Prognosis of leukemia relapse post allogeneic stem cell transplantation (alloSCT) is poor and effective new treatments are urgently needed. T cells are pivotal in eradicating leukemia through a graft versus leukemia (GVL) effect and leukemia relapse is considered a failure of GVL. T-cell exhaustion is a state of T-cell dysfunction mediated by inhibitory molecules including programmed cell death...

Discrete diagnostic subtypes of T lymphoblastic leukemia/lymphoma (T-cell acute lymphoblastic leukemia/lymphoma, T-ALL) have historically not been widely recognized. Recently, a novel subset with distinctive immunophenotypic, molecular, and clinical features has been proposed. Termed early T-cell precursor acute lymphoblastic leukemia (ETP-ALL), these cases seem to correspond to a very early st...

Adult T-cell Leukemia/Lymphoma (ATLL) is a rare aggressive malignancy associated with human leukemia virus type 1 (HTLV-1) infection. However, little known about the underlying activated molecular pathways at single cell level. Moreover, intercellular communications between tumor microenvironment (TME) and cells in this are currently unknown. Difficulties harvesting fresh tissue clinical settin...

patients with lymphoproliferative disorders have cellular immune deficiency and are susceptible to typical and atypical mycobacterial infections.hairy cell leukemia is a b-cell type lymphoproliferative disorder.2-cda is the choice of treatment for patients with hairy cell leukemia. it is a synthetic antineoplastic agent with immunosuppressive effects.we present development of pulmonary and meni...

Summary Leukemia and lymphoma are a leading cause of cancer-related mortality in children the prognosis for patients with relapsed or refractory disease remains poor. Standard therapies associated wide array acute long-term toxicities. Immunotherapy is changing treatment landscape pediatric leukemia has advanced at tremendous pace over last decade. Immunotherapies thought to exhibit fewer toxic...

Early T-cell precursor leukemia (early precursor, ETP-ALL) is a new subvariant of acute lymphoblastic (ALL). Tumor blasts have unique phenotype, including signs both stem and myeloid cells. This fact significantly complicates differential diagnosis. Cytogenetic molecular biological features cells in ETP-ALL are the most important diagnostic criteria. Nowadays leading scientific international gr...

The presence of terminal deoxynucleotidyl transferase (TdT) has been determined in neoplastic cells from 50 patients with non-hematologic tumors as well as neoplastic cells from 85 patients with hematologic malignancies. The results indicate that TdT is not present in cells from non-hematologic tumors, Hodgkin's lymphoma, B cell lymphoproliferative disorders, peripheral T cell neoplasms, reacti...