Nodal peripheral T-cell lymphomas are a rare group of neoplasms derived from post-thymic and activated T lymphocytes. A review of scientific articles listed in PubMed, Lilacs, and the Cochrane Library databases was performed using the term "peripheral T-cell lymphomas". According to the World Health Organization classification of hematopoietic tissue tumors, this group of neoplasms consists of ...

T-cell lymphoma is a heterogeneous group of diseases. Except for ALK positive anaplastic large cell lymphoma, T-cell lymphoma responds to conventional chemotherapy unfavourably, and most patients carry poor prognosis. In recent years, efforts have been made to improve the outcome of T-cell lymphoma patients. Novel agents, high-dose therapy, and allogeneic stem cell transplantation are studied, ...

Viral cell-free DNA (cfDNA) in plasma has been widely evaluated for detecting cancer and monitoring disease virus-associated tumors. We investigated whether the amount of cfDNA human T-cell leukemia virus type 1 (HTLV-1) correlates with state adult leukemia-lymphoma (ATL). HTLV-1 aggressive ATL was significantly higher than that indolent asymptomatic carriers. Notably, patients lymphoma represe...

The overlapping features of malignant lymphomas create a diagnostic "grey zone" , and lead to the invention of "grey zone lymphomas". There are several major grey zone lymphomas: 1) Lymphomas with overlapping features of Hodgkin lymphoma and large B-cell lymphoma; 2) Lymphomas with overlapping features of Burkitt lymphoma and diffuse large B-cell lymphoma; 3) Lymphomas with overlapping features...

We recently reported deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia. Functional analyses confirmed that PTPN2 acts as classical tumor suppressor repressing the proliferation of T cells, in part through inhibition of JAK/STAT signaling. We investigated the expression of PTPN2 in leukemia as well as lymphoma cell lines. We identified bi-allelic inac...

Immunoblastic lymphadenopathy (lBL)-like T-cell lymphoma is a distinct peripheral T-cell lymphoma. which closely resembles angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) and/or IBL. but is characterized by focal or sheet-like proliferation of immunoblasts and pale cells of T-cell nature. In this report. 36 patients with IBI-like T-cell lymphoma were analyzed. The disease is clini...

Peripheral T-cell lymphomas are a collection of rare diseases, most of which have a poor prognosis. The basic categories include precursor lymphoid neoplasms (eg, lymphoblastic lymphoma); mature natural killer/T-cell neoplasms and extranodal lymphomas, including enteropathy-associated T-cell lymphoma; hepatosplenic T-cell lymphoma; and subcutaneous panniculitis-like T-cell lymphoma. The most co...