To study the role of the host cell in bacteriophage T4 infection, we selected more than 600 mutant host-defective bacteria that absorbed and were killed by phage T4+ but were unable to support its growth. The mutants were grouped into seven classes by the growth patterns of T4 phages carrying compensating mutations (go mutants [grows on]), selected on four prototype host-defective strains. Lysi...

A growing number of studies have revealed that neurocognitive impairment, induced by adult-onset hypothyroidism, may not be fully restored by traditional hormone substitution therapies, including thyroxine (T4). The present study has investigated the effect of T4 and donepezil (DON; an acetylcholinesterase (AChE) inhibitor) treatment on the hypothyroidism-induced alterations of acetylcholine (A...

An experiment was conducted on laying quails to determine optimum dietary level of Ashwagandha supplementation on egg production and egg quality traits at Instructional poultry farm Nagla, GBPUA&T. Hundred quails were randomly distributed in four treatments and reared on standard managemental conditions. The root powder of Ashwagandha was added over the basal ration at 0.5% level (T2), 1% (T3),...

Hypothyroidism, defined as thyrotropin (TSH) above and free thyroxine (fT4) serum level below the reference rage, as well as hyperthyroidism, defined as suppressed TSH and elevated thyroid hormones exceeding the upper limit of the reference range, may have major impacts on fertility and pregnancy outcome. Ideally, euthyroidism, defined as TSH and fT4 in the reference range, should be establishe...

Differential effects of propylthiouracil (PTU), methimazole (MMI) and thyroidectomy (Tx) on liver and plasma proteins have been studied in rats, some of which have been simultaneously treated with L-thyroxine (T4). Although the absolute liver weights were lower in all hypothyroid groups, the relative liver weights (g/100 g) were significantly higher in PTU and MMI groups, while in Tx group they...