BACKGROUND In the literature, data concerning the relationship between breast cancer and HLA class II gene polymorphisms are limited, so the aim of this study was to determine if HLA-DQB1 and HLA-DRB1 MHC class-II alleles may confer susceptibility or resistance to the disease among Jordanian females. MATERIALS AND METHODS This case control study enrolled 56 Royal Hospital breast cancer patien...

The experiment was conducted to assess the impactofZn and B application on sunflower growth, yield oil content in sub-tropical condition. laid out randomized complete block design (RCBD) with twelve treatmentsand replicated thrice. treatments comprised viz; T1: Without fertilizers (absolute control), T2: RDF (N80P40K40), T3: N80P40K40Zn0.5%, T4: N80P40K40Zn4, T5: N80P40K40B0.2%, T6: N80P40K40B2...

BACKGROUND Despite many epidemiological reports concerning the efficacy of angiotensin-converting enzyme (ACE) inhibitors in dogs with mitral regurgitation (MR), the hemodynamic effects of ACE inhibitor administration have not been fully evaluated. OBJECTIVES To document left atrial pressure (LAP) in dogs with MR administered ACE inhibitors, in order to obtain interesting information about da...

We explored the association between HLA-B and HLA-DRB1 polymorphisms reviewed clinical characteristics of systemic lupus erythematosus (SLE) in Han population Yunnan, China. Methods There were 295 patients 265 healthy control subjects (HCs) enrolled study. Clinical data blood samples collected from patients. The genotypes detected SLE HCs. Results A total 74 on loci determined 288 as well 57 re...

BACKGROUND Polymorphic differences between human leukocyte antigen (HLA) molecules affect the specificity and conformation of their bound peptides and lead to differential selection of the T-cell repertoire. Mismatching during allogeneic transplantation can, therefore, lead to immunological reactions. DESIGN AND METHODS We investigated the structure-function relationships of six members of th...

BACKGROUND/AIMS Sympathetic ophthalmia (SO) is a classic example of autoimmune disease where human leucocyte antigen (HLA) genomic associations could provide further understanding of mechanisms of disease. This study sought to assess HLA genetic polymorphism in British and Irish patients with SO, and to assess whether HLA gene variants are associated with clinical phenotype or disease severity....

The changes in distribution and turnover of T6+ Langerhans cells (LC) in the skin during delayed immune responses to tuberculin, and in the lesions of tuberculoid leprosy and cutaneous Leishmaniasis were investigated. In each situation, there was a dermal accumulation of monocytes and T cells and epidermal thickening with keratinocyte Ia expression. In the tuberculin response a dramatic change ...

Leptin plays a key role in the regulation of the energy balance in mammals. Thus, the leptin and leptin receptor are being intensively studied in these animals. However, it remains unclear whether the leptin-mediated control mechanism is conserved in nonmammalian vertebrates such as the avian. In this study, the association of the SNP LEPR A286G with carcass traits was investigated in the EMBRA...

We studied the frequencies of human leukocyte antigen alleles (A, B, and DRB1) in 90 patients with acute lymphoblastic leukemia (ALL) and then compared them with 126 controls in this study. Although the frequencies of the A*03 allele, the DRB1*03 allele, the DRB1*04 allele, the A*02/B*35/DRB1*13 haplotype, and homozygosity of A*02 were higher in patients (p=0.006, p=0.003, p=0.002, p=0.01, and ...

Canadian oil sands are unconsolidated sand deposits that are impregnated with heavy, viscous petroleum, normally referred to as bitumen. The total bitumen in place in Alberta is estimated at 1.7 to 2.5 trillion barrels and is clearly massive by world standards. Presently, 25% of the Canadian energy needs are derived from upgraded bitumen from mined oil sands. The oil sands are a complex mixture...