Despite major therapeutic advances in the management of patients with systemic malignancies, management of brain metastases remains a significant challenge. These patients often require multidisciplinary care that includes surgical resection, radiation therapy, chemotherapy, and targeted therapies. Complex decisions about the sequencing of therapies to control extracranial and intracranial dise...

The variety of treatment options for cancer patients has increased significantly in recent years. Not only do we combine radiation with surgery and chemotherapy, new therapeutic approaches such as immunotherapy and targeted therapies are starting to play a bigger role. Physics has made significant contributions to radiation therapy treatment planning and delivery. In particular, treatment plan ...

Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world. Surgery offers the only hope for cure. However, the potentially curable method is only possible for a small proportion of those afflicted, for the rest, palliative treatment is indicated. Despite all the treatment options when used as monotherapy, patients with HCC have a poor long term prognosis. In this setting, mult...

Radiation therapy (RT) is one of the highly effective treatments option for clinically advanced tumor, and plays a prominent role in cancer therapy and prognosis. It is estimated that 62% of newly diagnosed cancer patients are treated with radiation therapy [1]. The efficacious radiation therapy depends upon the homogenous delivery of total dose which could eliminate tumor cells while protectin...

PURPOSE Tookad is a novel intravascular photosensitizer. When activated by 763 nm light, it destroys tumors by damaging their blood supply. It then clears rapidly from the circulatory system. To our knowledge we report the first application of Tookad vascular targeted photodynamic therapy in humans. We assessed the safety, pharmacokinetics and preliminary treatment response as a salvage procedu...

BACKGROUND Image-guided radiotherapy used multiple imaging during the radiation therapy course to improve the precision and accuracy of health care provider's treatment. OBJECTIVES This study aims to assess the safety, effectiveness and economic aspects of image-guided radiation therapy for decision-making about this technology in Iran. METHODS In this study, the most important medical data...

CUP syndrome (cancer of unknown primary) describes the presence histologically proven metastases in an primary tumor. It affects about 3–5% all tumor patients. The search for makes extensive diagnostics necessary. However, 2/3 patients original is not discovered. Operation, radiation, chemotherapy and, some cases, targeted therapy are available as treatment. prognosis unfavorable.

Though early stage head and neck cancers can be cured either by surgery or radiation, patients with locally advanced disease continues to pose a therapeutic challenge. Locoregional failure is the major cause of death in head and neck cancers. As the outcome of locally advanced head and neck cancer is less than promising, a combined modality approach is generally undertaken in this group of pati...

Management of recurrent endometrial carcinoma has traditionally focused on providing targeted adjuvant therapy in select groups of patients based on their risk factors. Major progress has been made over the last two decades in identifying these clinical-pathological risk factors, which has led to the classification of patients into different risk groups. Patients with high-risk factors are gene...