intraoperative radiation therapy (iort) is a multidisciplinary approach in which residual tumors or tumor beds are directly irradiated during a surgical procedure. to evaluate its efficacy, from 1985, we conducted a prospective study including non-metastatic gastric adenocarcinoma treated by surgery, iort (15 grays) and postoperative external beam radiotherapy (44 grays). up to 1993, 51 cases o...

introduction magnetic fields are capable of altering the trajectory of electron beams andcan be used in radiation therapy.theaim of this study was to produce regions with dose enhancement and reduction in the medium. materials and methods the ndfeb permanent magnets were arranged on the electron applicator in several configurations. then, after the passage of the electron beams (9 and 15 mev va...

Immunotherapy is increasingly being applied in conjunction with any of the three commonly accepted treatment modalities of surgery, chemotherapy, and radiation therapy in the treatment of solid and hematological malignancies. Radiation therapy, which can be applied as a monotherapy, has immunostimulatory properties that are specifically augmented when used together with immunotherapy. High-dose...

hodgkin lymphoma (hl) accounts for about 10% of all childhood cancers. five-year survival rates with modern therapies are now approaching >90-95% as a consequence of its significant sensitivity to both chemotherapy and radiation. the current challenge is to determine how much therapy is needed to improve survival and how to adapt treatment to the patient to prevent these long term toxicities. t...

Combination therapy for lung cancer has garnered widespread attention. Radiation therapy, gene therapy, and molecular targeted therapy for lung cancer have certain effects, but the disadvantages of these treatment methods are evident. Combining these methods can decrease their side effects and increase their curative effects. In this study, we constructed a pYr-ads-8-5HRE-cfosp-iNOS-IFNG plasmi...

An intercomparison of microdosimetric and nanodosimetric quantities simulated Monte Carlo codes is in progress with the goal assessing uncertainty contribution to results due uncertainties electron interaction cross-sections used codes. In first stage intercomparison, significant discrepancies were found for as well simulations a radiation source placed at surface spherical water scoring volume...

Cell damage by high LET radiations has been described by a phenomenological model (track theory) for 20 years and more. Molecules of biological significance (dry enzymes and viruses) act as 1 hit detectors. Recent additions to the class of I-hit detectors are E. Coli B, and the creation of both single and double strand breaks in SV-40 virus in EO buffer, where indirect effects predominate. The ...

Targeted radionuclide therapy, which is based on the selective delivery of a sufficient radiation dose to tumors without significantly affecting normal tissues, is a promising therapeutic approach for the treatment of a wide variety of malignancies. Integrins, a family of cell adhesion molecules, play key roles during tumor angiogenesis and metastasis. Among all the integrins, αvβ3 seems to be ...