نتایج جستجو برای: tau convolution
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Stem cell (SC) lines that capture the genetics of disease susceptibility provide new research tools. To assess the utility of mouse central nervous system (CNS) SC-containing neurosphere cultures for studying heritable neurodegenerative disease, we compared neurosphere cultures from transgenic mice that express human tau with the P301L familial frontotemporal dementia (FTD) mutation, rTg(tau(P3...
Objective(s): Metastasis is the main cause of death in patients with melanoma. Cannabis-based medicines are effective adjunctive drugs in cancer patients. Tau and Stathmin proteins are the key proteins in cancer metastasis. Here we have investigated the effect of a standardized Cannabis sativa extract on cell migration and Tau and Stathmin gene expression in the melanoma cell line. Materials an...
Convolution and correlation are very basic image processing operations with numerous applications ranging from image restoration to target detection to image resampling and geometrical transformation. In real time applications, the crucial issue is the processing speed, which implies mandatory use of algorithms with the lowest possible computational complexity. Fast image convolution and correl...
Using a sample of tagged D(s)(+) decays collected near the D(s)(*+/-)D(s)(-/+) peak production energy in e(+)e(-) collisions with the CLEO-c detector, we study the leptonic decay D(s)(+)-->tau(+)nu(tau) via the decay channel tau(+)-->e(+)nu(e)nu(tau). We measure B(D(s)(+)-->tau(+)nu(tau))=(6.17+/-0.71+/-0.34)%, where the first error is statistical and the second systematic. Combining this resul...
INTRODUCTION Accumulation of insoluble conformationally altered hyperphosphorylated tau occurs as part of the pathogenic process in Alzheimer's disease (AD) and other tauopathies. In most AD subjects, wild-type (WT) tau aggregates and accumulates in neurofibrillary tangles and dystrophic neurites in the brain; however, in some familial tauopathy disorders, mutations in the gene encoding tau cau...
BACKGROUND Intracellular filamentous deposits containing microtubule-associated protein tau constitute a defining characteristic of many neurodegenerative disorders. Current experimental models to study tau pathology in vitro do not usually recapitulate the tau expression pattern characteristic of adult human brain. In this study, we have investigated whether human embryonic stem cell-derived n...
The hyperphosphorylated microtubule-associated protein tau is present in several neurodegenerative diseases, although the causal relationship remains elusive. Few mouse models used to study Alzheimer-like dementia target tau phosphorylation. We created an inducible pseudophosphorylated tau (Pathological Human Tau, PH-Tau) mouse model to study the effect of conformationally modified tau in vivo....
We have reported previously a tau transgenic mouse model (Tg30tau) overexpressing human 4R1N double-mutant tau (P301S and G272V) and that develops AD (Alzheimer's disease)-like NFTs (neurofibrillary tangles) in an age-dependent manner. Since murine tau might interfere with the toxic effects of human mutant tau, we set out to analyse the phenotype of our Tg30tau model in the absence of endogenou...
Fig. 4. Analysis of fully fed vs DR food effects on tau levels and phosphorylation in flies over-expressing WT human tau. (A) Tau expression and phosphorylation levels were measured by western blotting in control flies (welav/+, w;UAS-4Rtau/+), and at the indicated time points in welav/+;UAS-4Rtau/+flies treated on1.0 vs 2.0 Y medium. Primary antibodies were as follows: Anti-tau (total tau; Dak...
6 The convolution layer 13 6.1 What is a convolution? . . . . . . . . . . . . . . . . . . . . . . . . 13 6.2 Why to convolve? . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 6.3 Convolution as matrix product . . . . . . . . . . . . . . . . . . . 18 6.4 The Kronecker product . . . . . . . . . . . . . . . . . . . . . . . 20 6.5 Backward propagation: update the parameters . . . . . . . . ...
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