Traumatic brain injury (TBI) patients are known to be at high risk for venous thromboembolic events (VTEs). The Brain Trauma Foundation Guidelines (2007) state that low-molecular-weight heparin or unfractionated heparin should be used to prevent VTE complications, but suggest that there is an increased risk of expansion of intracranial hemorrhages (ICH) with VTE prophylaxis. In addition, it is ...

In practical situations, we observe the number of claims to an insurance portfolio but not the claim intensity. It is therefore of interest to try to solve the` ltering problem', that is to obtain the best estimate of the claim intensity on the basis of reported claims. In order to use the Kalman-Bucy lter, based on the Cox process incorporating a shot noise process as claim intensity, we need ...

Objective(s): While traumatic brain injury (TBI) is a predisposing factor for development of post-traumatic epilepsy (PTE), the occurrence of seizures following brain trauma can infuriate adverse consequences of brain injury. However, the effect of seizures in epileptogenesis after mild TBI cannot yet be accurately confirmed. This study was designed to investigate the ...

Clinical observations show that older patients do not tolerate high-dose chemoradiotherapy as well as younger patients. It is unclear whether this is due to age-related differences in their responses to hematopoietic injury or to differential toxicities to other organs. In the present study, 6 young (0.5 years) and 6 elderly (8 years) dogs were challenged with 7 repeated nonlethal doses of 50 o...

Oral busulfan is an alkylating agent that provides good antileukemic activity and excellent CNS penetration. It was first introduced over 30 years ago by George Santos as an alternative to total body irradiation (TBI) for preallogeneic transplantation conditioning [1]. Since its introduction, it has had a mixed reputation. Oral busulfan (PO BU) proved an attractive alternative to TBI based on g...

A respiratory chamber is used for monitoring VO2, VCO2 and RQ in humans, enabling long term (24h) observation under free living conditions. Computation of VO2 and VCO2 is currently done by inversion of a mass balance equation, with no consideration of measurement errors and other uncertainties. In order to improve the accuracy of the results, a new mathematical model is suggested in the present...

traumatic brain injury (tbi) is one the most common cause of disability between young adults. these people have been socially isolated during post-surgery traumatic brain injury. in this study we investigated the effect of social isolation on the structural deficits after tbi in the young rats. young rats were divided into control group with social interaction, sham group with social isolation ...