We present an autopsy case of primary leptomeningeal melanoma visualized with technetium-99m-hexamethylpropyleneamine oxime (Tc-99m-HMPAO) single photon emission CT (SPECT) of the brain. Increased uptake of Tc-99m-HMPAO coincided with leptomeningeal enhancement on MR images and with the tumor location of the autopsy findings. It was thought that Tc-99m-HMPAO could correlate closely with melanom...

PURPOSE To compare the potential application of (99m)Tc-3P-Arg-Gly-Asp ((99m)Tc-3P4-RGD2) scintimammography (SMM) and (99m)Tc-methoxyisobutylisonitrile ((99m)Tc-MIBI) SMM for the differentiation of malignant from benign breast lesions. METHOD Thirty-six patients with breast masses on physical examination and/or suspicious mammography results that required fine needle aspiration cytology biops...

Our goal was to validate the feasibility of(99m)Tc-duramycin as a potential apoptosis probe for monitoring tumor response to paclitaxel in breast cancer xenografts. The binding of(99m)Tc-duramycin to phosphatidylethanolamine was validated in vitro using paclitaxel-treated human breast carcinoma MDA-MB-231 cells. Female BALB/c mice (n = 5) bearing breast cancer xenografts were randomized into 2 ...

twenty-one patients with medullary thyroid carcinoma were studied prospectively with tc-99m (v) dmsa after surgery. pentavalent dmsa scintigram demonstrated abnormal uptake in 13 and equivocal uptake in 6 patients. finally, seven patients with surgical or other imaging documentation were selected for this paper. most of these patients were asymptomatic. six patients had hypercalcitonemia and se...

Correspondence to: Venkatesh L. Murthy, MD, PhD, 1338 Cardiovascular Center, 1500 E Medical Center Drive, SPC 5873, Ann Arbor, MI 48109-5873. E-mail [email protected] Venkatesh L. Murthy, MD, PhD Leslee J. Shaw, PhD Brahmajee K. Nallamothu, MD, MPH In the United States, single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI) accounts for the overwhelming majorit...

UNLABELLED The aim of this study is to assess the accuracy of the pre-existing single-plasma-sample method (SPSM) to measure the glomerular filtration rate (GFR) with Tc-99m-diethylenetriamine pentaacetic acid (Tc-99m-DTPA) in children and adolescents. In addition, the age-independent SPSM is evaluated with two algorithms (Bubeck and Russell) applied for Tc-99m-mercaptoacetyltriglycine (Tc-99m-...

BACKGROUND AND PURPOSE The arterial and venous blood concentration of technetium 99m-labeled hexamethylpropyleneamine oxime ((99m)Tc-HMPAO) reaches an equilibration more rapidly than other CBF tracers. We hypothesized that (99m)Tc radioactivity of a venous sample at equilibrium, which is similar to that of an arterial sample, would allow estimation of the integrated input function for the clini...

99mTc-octreotide scintigraphy, performed during the following up a 58-year old man with neuroendocrine tumor demonstrated massive hepatomegaly demonstrating multiple areas of increased and decreased uptake. Due to severe hepatomegaly concurrence of any other abdominal soft tissue lesions could not be excluded. A 99mTc-sulfur colloid scan was done and thoroughly compared wi...

bone involvement. Destruction is mediated through normal osteoclasts, which respond to local osteoclast-activating microenvironment [7]. Technetium-99m 2methoxyisobutylisonitrile (TC-99m MIBI) is a lipophilic agent that accumulates within living malignant cells due to the higher transmembrane electrical potential as a consequence of the higher metabolic rate than in the surrounding normal cells...

Technetium-99m (Tc-99m) teboroxime is a new perfusion tracer that is highly extracted and rapidly cleared by the myocardium. To determine the feasibility of Tc-99m teboroxime imaging in the diagnosis of patients with suspected coronary artery disease, 30 patients underwent single photon emission computed tomography imaging with Tc-99m teboroxime (25.2 +/- 1 mCi) at peak exercise and again 60 mi...