Alloreactivity is one ofthe most puzzling phenomena in immunology. Quite some time ago it was discovered that an individual's T lymphocytes are highly reactive to cells from another individual when they express different (allelic, allogeneic) MHC molecules (1, 2) . The reactive T lymphocytes must occur at high frequency, as 1-4% ofvirgin T cells are capable of responding across any given MHC di...

Squamous Cell Carcinoma (SCC) is a type of non-melanoma skin cancer prevalent in immune-suppressed transplant recipients and older individuals with a history of chronic sun-exposure. SCC itself is believed to be a late-stage manifestation that can develop from premalignant lesions including Intraepidermal Carcinoma (IEC). Notably, while SCC regression is rare, IEC typically regresses in respons...

The thymidine (dThd) and hypoxanthine (Hyp) requirements for protection of normal human granulocyte-macrophage col ony-forming units, B-, and T-cells against methotrexate-induced inhibition of proliferation were compared to require ments of three malignant solid-tumor cell lines recently estab lished from human tumor xenografts and of the CCRF-CEM Tcell leukemia. In the presence of excess Hyp, ...

Human T cells genetically modified to express chimeric antigen receptors (CAR) specific to the B cell tumor antigen CD19 can successfully eradicate systemic human CD19þ tumors in immunocompromised SCID (severe combined immunodeficient)-Beige mice. However, in the clinical setting, CD4þ CD25 T regulatory cells (Treg) present within the tumor microenvironment may be potent suppressors of tumor-ta...

Spleen and bone marrow cells from DBA/2 mice protected against infection with a leukemogenic dose of Friend leukemia virus (FLV) by passive therapy with chimpanzee anti-FLV serum were shown to be able to adoptively transfer antiviral resistance to unimmunized irradiated syngeneic recipients. Similar to the results obtained with donor mice immunized against a synge neic FLV erythroleukemia cell ...

BACKGROUND Rheumatoid arthritis (RA) is an inflammatory rheumatic disease associated with a dysfunction of the T cell-mediated tolerance and leading to the disability of working population. The regulatory CD4' T cells play an important role in the regulation of autoimmunity and can suppress immune responses. With that, there is no consensus on the content of these lymphocytes and their role in ...

A shift from Th1to Th2-type cell immune response has been suggested to occur during sepsis, contributing to cell-mediated immunity suppression and to poor prognosis. The aim was to study the relationship between old and new Th2 markers and the clinical outcome of sepsis. 30 critically ill patients with sepsis for 48 hours were enrolled in a prospective clinical study. Blood samples were collect...

Bronchial γδ T-lymphocytes and expression of heat shock proteins in mild asthma. I. Fajac, G.L. Roisman, J. Lacronique, B.S. Polla, D.J. Dusser. ERS Journals Ltd 1997. ABSTRACT: Heat shock proteins (HSPs), which are important targets for γδ Tlymphocytes, are thought to play a role in inflammatory and immune diseases. The purpose of this study was to characterize, in asthma, the presence and di...

The thymidine (dThd) and hypoxanthine (Hyp) requirements for protection of normal human granulocyte-macrophage col ony-forming units, B-, and T-cells against methotrexate-induced inhibition of proliferation were compared to require ments of three malignant solid-tumor cell lines recently estab lished from human tumor xenografts and of the CCRF-CEM Tcell leukemia. In the presence of excess Hyp, ...

Dysbalance in gut microbiota has been linked to increased microbial translocation, leading to chronic inflammation in HIV-patients, even under effective HAART. Moreover, microbial translocation is associated with insufficient reconstitution of CD4+T cells, and contributes to the pathogenesis of immunologic non-response. In a double-blind, randomised, placebo-controlled trial, we recently showed...