Schizophrenia is a devastating psychiatric disorder that affects 1% of population worldwide. Neuroleptics are the major class of drugs used in the treatment of schizophrenia. Neuroleptics are associated with wide variety of extrapyramidal side effects such as akathesia, dystonia, neuroleptic malignant syndrome, Parkinsonism and tardive dyskinesia. tardive dyskinesia is a complex hyperkinetic sy...

Thiadiazoles are one of the most widely utilized agents in medicinal chemistry, having a wide range of pharmacologic activity. Microtubules (MTs) have always remained a sought-after target in rapidly proliferating cancer cells. We screened for the growth inhibitory effect of synthetic 5-(3-indolyl)-2-substituted-1,3,4-thiadiazoles on cancer cells and identified NMK-TD-100, as the most potent ag...

Age-related differences in temporal discounting (TD) and risk-taking, and their association, were examined in adolescents and young adults (n = 337) aged 12-27 years. Since monetary rewards are typically used in TD and risk-taking tasks, the association between monetary reward valuation and age and decision-making in these tasks was explored as well. TD declined linearly with age, with a partic...

Resumen. La toma de decisiones (TD) es una trascendental habilidad en cargos de alta dirección organizacional. Allí, diferentes actividades ejercidas pueden ser comprendidas dentro del concepto de negociación, el cual tiene un estrecho vínculo con la TD. La TD no programadas son llevadas a cabo por una persona en escenarios atípicos donde la información es ambigua y conlleva la implementación d...

This paper describes the results of applying Temporal Difference (TD) learning with a network to the opening game problems in Go. The main difference from other research is that this experiment applied TD learning to the fullsized (19×19) game of Go instead of a simple version (e.g., 9×9 game). We discuss and compare TD(λ) learning for predicting an opening game’s winning and for finding the be...

Age-related differences in temporal discounting (TD) and risk taking, and their association, were examined in adolescents and young adults (n = 337) aged 12-27 years. Since monetary rewards are typically used in TD and risk-taking tasks, the association between monetary reward valuation and age and decision making in these tasks was explored as well. TD declined linearly with age, with a partic...

BACKGROUND Thyroid dysfunction (TD) represents an extra-hepatic manifestation of chronic hepatitis C (CHC) and it may also be a side effect of interferon-alpha (IFN-α) based treatment. However, previous studies have shown a wide variation in the incidence of TD in patients with CHC. Furthermore, the long-term outcomes and the predictive factors of TD in patients who receive IFN-α based treatmen...

In this work, a model is developed to treat threading dislocation (TD) reduction in (0 0 0 1) wurtzite epitaxial GaN thin films. The model is based on an approach originally proposed for (0 0 1) FCC thin film growth and uses the concepts of mutual TD motion and reactions. We show that the experimentally observed slow TD reduction in GaN can be explained by low TD reaction probabilities due to T...

Over the last years evidence on the overlap between tic-disorders (TD) and obsessive compulsive behavior/disorder (OCB/OCD) has increased. The main focus of research have been the phenomenological and epidemiological similarities and differences in samples of different age, primary diagnosis (TD vs. OCD) including the co-occurrence of both. Unfortunately, only a minority of studies included all...

In reinforcement learning, the TD(λ) algorithm is a fundamental policy evaluation method with an efficient online implementation that is suitable for large-scale problems. One practical drawback of TD(λ) is its sensitivity to the choice of the step-size. It is an empirically well-known fact that a large step-size leads to fast convergence, at the cost of higher variance and risk of instability....