Tec family nonreceptor tyrosine kinases are key immunological enzymes that control processes that range from T and B cell development to reorganization of the actin cytoskeleton. The full-length Tec kinases have been resistant to crystallization. This lack of structural data and the paucity of in vitro biochemical data for this kinase family leave a void in our understanding of Tec kinase regul...

Ingestion of aristolochic acid (AA) can cause AA nephropathy (AAN), in which excessive death of tubular epithelial cells (TECs) characterize the acute phase. AA forms adducts with DNA, which may lead to TEC apoptosis via p53-mediated signaling. We tested this hypothesis both by studying p53-deficient mice and by blocking p53 in TECs with its inhibitor pifithrin-alpha. AA induced acute AAN in wi...

BACKGROUND The addition of anthracyclines to platinum-based chemotherapy may provide benefit in survival in ovarian cancer patients. We evaluated the effect on survival of adding epirubicin to standard carboplatin and paclitaxel. PATIENTS AND METHODS We carried out a prospectively randomized phase III study comparing carboplatin plus paclitaxel (TC; area under the curve 5 and 175 mg/m(2)) wit...

-This study is a preliminary analysis of the accuracy of various ionosphere models to correct single frequency altimeter height measurements for ionospheric path delay. In particular, research focused on adjusting empir/cal and parameterized ionosphere models in the parameterized real-time ionospheric specification modal (PRISM) 1.2 using total electron content (TEC) data from the global positi...

In the present work we use the NASA-JPL global ionospheric maps of total electron content (TEC), firstly to construct TEC maps (TEC vs. magnetic local time MLT, and magnetic latitude MLAT) in the interval from 1999 to 2005. These TEC maps were, in turn, used to estimate the annualto-mean amplitude ratio, A1, and the semiannual-to-mean amplitude ratio, A2, as well as the latitudinal symmetrical ...

The forkhead transcription factor Foxn1 is indispensable for thymus development, but the mechanisms by which it mediates thymic epithelial cell (TEC) development are poorly understood. To examine the cellular and molecular basis of Foxn1 function, we generated a novel and revertible hypomorphic allele of Foxn1. By varying levels of its expression, we identified a number of features of the Foxn1...

The impact of space weather events on satellitebased technologies (e.g. satellite navigation and precise positioning) is typically quantified on the basis of the total electron content (TEC) and temporal fluctuations associated with it. GNSS (global navigation satellite systems) TEC measurements are integrated over a long distance and thus may include contributions from different regions of the...

Rat thymic epithelial cells (TEC) in long-term culture were characterized by anticytokeratin monoclonal antibodies (mAbs) and electron microscopy. Phenotypic analysis performed by a large panel of mAbs showed that the highest percentage of these cells was of the subcapsular/medullary type. Recombinant rat interferon (IFN)-gamma up-regulated class-I and class-II MHC expression by TEC in culture ...

The Cand-Tec Candida detection system and enzyme immunoassay for serum mannan were retrospectively compared in a controlled collaborative evaluation of antigen detection in 32 patients with candidiasis proven by biopsy or culture from a normally sterile site and with sera drawn within 7 days of inclusion. With a threshold titer of 1/8, which excluded false-positive results in 17 hospitalized pa...

We present; t,wo new t.~·r·ln!iqnr:-s for con~l.rnct.ing 1.EC/AUED codes. The cnmbiu~t.ion 'lf the l.wn L<'c!tniqnf"s rednce!l the t,otal rednnda.nry of t,h,. hr:-st r·nnsl.rll(~tions hy on" hit. or 11101'<' in 111<1.ny c<J.SPS.