SEVERAL OPTIONS FOR THE TREATMENT OF HEPATITIS B HAVE BEEN LICENSED IN THE LAST YEARS: interferon, pegylated interferon, lamivudine, adefovir, entecavir, and telbivudine. In addition tenofovir has been licensed in the EU and is expected to be licensed in the USA in 2008. The antivirals can be divided into "lamivudine-like" and "adefovir-like", which clinically differ in their capacity to induce...

method of glomerular filtration rate (clearance rate of the endogenous creatinine). Like low dose (11 mg/kg) of adefovir, low dose of tenofovir only also caused minor effects on the renal structure while higher doses of tenofovir caused severely gastrointestinal toxicity within 2 weeks. No renal toxicity was seen for either entecavir or telbivudine, highlighting a high degree of safety compared...

While 25 compounds have been formally licensed for the treatment of HIV infection (AIDS), only seven licensed products are currently available for the treatment of chronic hepatitis B virus (HBV) infection: interferon-α, pegylated interferon-α, lamivudine, adefovir (dipivoxil), entecavir, telbivudine and tenofovir (disoproxil fumarate). In contrast to the treatment of HIV infections where the i...