The contribution of recent trials such as the extensive ONTARGET (ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial) ‘a thorough, double-blind, prospective, randomised trial, which documents the equal-outcome efficacy of an ARB (telmisartan) and an ACE inhibitor in a high-risk population’ is noted in a recent meta-analysis of ARBs. Among ARBs, telmisartan is furth...

Cardiovascular risk reduction has been the target of several large clinical trials in the last decade. As the activation of the renin-angiotensin-aldosterone system (RAAS) plays a central role in the pathogenesis of atherosclerosis and cardiovascular disease, RAAS blockade has been suggested to be among the most efficient cardioprotective interventions, as revealed with the angiotensin converti...

Because endothelial nitric oxide synthase (eNOS) has anti-inflammatory and anti-arteriosclerotic functions, it has been recognized as one of the key molecules essential for the homeostatic control of blood vessels other than relaxation of vascular tone. Here, we examined whether telmisartan modulates eNOS function through its pleiotropic effect. Administration of telmisartan to mice significant...

Hypertension is a cardiovascular disease that manifests itself with continuous increase in systemic arterial blood pressure and can lead to serious complications over time. It estimated 37% of hypertensive patients receive treatment one-third them are under control. Telmisartan an angiotensin receptor blocker used the hypertension. Uridine 5'-diphospho-glucuronyltransferase 1 (UGT1A1) gene enco...

Introduction. A fixed dose combination of telmisartan and hydrochlorothiazide is indicated for treatment in the arterial hypertension. The these substances causes an additive effect that helps to reduce blood pressure. bioequivalence study Telzap ® Plus compared with MikardisPlus was conducted 63 volunteers. Aim. purpose trial a comparative pharmacokinetics evidence drug product (tablets 80 mg ...

Background and Objectives: Peroxisome proliferator-activated receptor- (PPAR-) is a nuclear receptor whose activation regulates inflammation and fibrosis in various organs. We aimed to investigate the effect of two PPAR- ligands, telmisartan and rosiglitazone, on lung injury and fibrosis induced by intratracheal bleomycin (BLM). Methods: Lung injury and fibrosis was induced in female C57Bl/6...

Blockade of the renin-angiotensin system is an important approach in managing high blood pressure, and has increasingly been shown to affect cardiovascular disease processes mediated by angiotensin II throughout the cardiovascular and renal continua. Telmisartan is an angiotensin II receptor blocker (ARB) displaying unique pharmacologic properties, including a longer half life than any other AR...

The therapeutic usefulness of doxorubicin (DXR), an anthracycline antibiotic, is limited by its cardiotoxicity. The present study investigated the effects of telmisartan, an angiotensin II receptor (AT1) antagonist against doxorubicin-induced cardiotoxicity in rats using biochemical and histopathological approaches. Doxorubicin (20 mg/kg) was injected intraperitoneally (ip) as a single dose and...

Background Combination therapy has been shown to improve cardiovascular outcomes in hypertensive, diabetic patients. Amlodipine demonstrates beneficial pleiotropic effects including improved endothelial function, enhanced angiogenesis, and reduced cardiovascular risk. Telmisartan exhibits similar beneficial cardiovascular effects in diabetic patients. Amlodipine in combination with telmisartan ...