In the last few decades, polymeric nanoparticles have been emerged as a most promising and viable technology for targeted controlled delivery of drugs well bioactive compounds such genes, drugs, nucleic acids proteins among other things, in biomedical pharmaceutical applications. They not only improve solubility, bioavailability, circulation time previous medications, but they can also be tailo...

pH responsive core–shell nanobowl-microstructures (NB-shells) as novel and exciting platforms for stimuli activated drug delivery applications.

This work describes the design and preparation of a simple but novel hybrid amphiphile containing a pH-responsive DNA sequence. The formation of a bimolecular i-motif structure allows the control of reversible switching of the hybrid amphiphile between the dimer and unimer by pH. Thus, spherical aggregates with distinct self-assembly pathways, sizes and structures are obtained at pH 4.5 and pH ...

Stimulus-responsive hydrogels have been widely used in the field of drug delivery because their three-dimensional pore size and ability to change release rate with external environment. In this paper, temperature-sensitive monomer 2-methyl-2-acrylate-2-(2-methoxyethoxy-ethyl) ethyl ester (MEO2MA) oligoethylene glycol methyl ether methacrylate (OEGMA) as well pH-sensitive N,N-Diethylaminoethyl (...

Objective(s) Physiological changes in the body may be utilized as potential triggers for controlled drug delivery. Based on these mechanisms, stimulus-responsive drug delivery has been developed. Materials and Methods In this study, a kind of poly (N-isopropylacrylamide-acrylamide) membrane was prepared by radical copolymerization. Changes in swelling ratios and diameters of the membrane wer...

We report here a hepatoma-targeting multi-responsive biodegradable crosslinked nanogel, poly(6-O-vinyladipoyl-D-galactose-ss-N-vinylcaprolactam-ss-methacrylic acid) P(ODGal-VCL-MAA), using a combination of enzymatic transesterification and emulsion copolymerization for intracellular drug delivery. The nanogel exhibited redox, pH and temperature-responsive properties, which can be adjusted by va...

abstract because of relation between digestive enzyme activity and feeding of insects that directly is in relation with the damage of insects; studying digestive enzyme systems is important in finding new control methods based on inhibiting digestive enzyme activity. recently using transgenic plants containing enzyme inhibitors is important in improving resistance of crops to pests because of s...

Structural variety, tunable porosity and opportunities for functionalization make metal-organic frameworks (MOFs) promising materials applications in medicine as drug delivery systems. In this minireview, an overview of chemical stability MOF nanocarriers at simulated body conditions is presented. Parameters such a choice buffer, pH value, nanoparticle size or surface modification are discussed...