Design Based Research (DBR) is a new and still-emerging approach to research about design, learning, and allied areas. This article reports one designer’s experiences within a DBR project. Whereas most reports of DBR focus on the outcomes of the design itself, the current paper offers a hermeneutical perspective by focusing on the personal narrative of the designer. Using Edelson’s (2002) categ...

Based on a review of existing literature in management and economics of arts and culture and on an extensive case study – the metropolitan museum district in Turin – this paper’s objective is to show that museum growth is problematic in the long term through a system dynamics model. The classical loop – investments, growth, profitability, investment – encounters difficulties when dealing with p...

Children with medulloblastoma in Bristol are treated surgically and with craniospinal irradiation, and in some cases chemotherapy. Thirteen medium or long term survivors were investigated to determine their growth and endocrine function. Their rate of growth was considerably reduced through the first year of their illness and after spinal irradiation spinal growth was poor. Nine children develo...

The purpose of our study is to identify the nature link between government spending and economic growth, in order test two theories Wagner Keynes, case Romania. On one hand, Keynes argues that public an important tool stimulate growth. other says increased a result We analyzed long-term dynamics time series through Johansen’s cointegration approach and, short term, with help Granger’s causality...

Pediatric liver transplantation has changed the poor prognosis for children with liver failure, some metabolic diseases and liver tumors. With the increase of survival, long-term maintenance has become a priority. Therefore, obtaining appropriate nutrition, physical growth, bone metabolism, endocrine function and psychosocial development has become one of the most important long-term objectives...

Nerve growth factor (NGF) is produced in the hippocampus throughout life and is retrogradely trafficked to septal cholinergic neurons, providing a potential mechanism for modulating cholinergic inputs and, thereby, hippocampal plasticity. To explore NGF modulation of hippocampal plasticity and function, NGF levels were augmented or blocked in intact adult rats, and subsequent in vivo effects on...

GAP-43 is a 25 kDa neuronal intrinsically disordered protein, highly abundant in the neuronal growth cone during development and regeneration. The exact molecular function(s) of GAP-43 remains unclear but it appears to be involved in growth cone guidance and actin cytoskeleton organization. Therefore, GAP-43 seems to play an important role in neurotransmitter vesicle fusion and recycling, long-...

Laboratory ecotoxicity tests may not adequately evaluate the effects of pesticides, because they often do not include more environmentally relevant conditions, such as pulsed toxicant exposures and low food conditions. Therefore, we tested the effects of a pulse of the pyrethroid insecticide fenvalerate (FV) on the life history and population growth rate (r) of the cladoceran Daphnia magna. The...

Does the spacing of time intervals used for model input data have an impact on the model’s subsequent calibration and so projections of land use change and urban growth? This study evaluated the performance of the SLEUTH urban growth and land use change model through two independent model calibrations with different temporal extents (1972 to 2006 vs. 2000 to 2006) for the historical Italian cit...