A study was conducted to examine the relationship of testicular atrophy to bone metabolism in male leprosy patients. The study consisted of 31 leprosy patients (mean age: 62.0 years) and 31 healthy control men (mean age: 60.0 years). Measurements were made of their serum levels of free testosterone (FT), estradiol (E2), luteinizing hormone (LH) and 25-hydroxyvitamin D (25 OHD). Bone mineral den...

Cimetidine, an H₂ receptor antagonist used for treatment of gastric ulcers, exerts antiandrogenic and antiangiogenic effects. In the testes cimetidine impairs spermatogenesis, Sertoli cells and peritubular tissue, inducing apoptosis in the myoid cells. Regarding the importance of histamine and androgens for vascular maintenance, the effect of cimetidine on the structural integrity of the testic...

BACKGROUND Division of lymphatic vessels during varicocelectomy could lead to hydrocele formation and decrease in testicular function due to testicular edema. We determined if the use of methylene blue combined with optical magnification reduces the incidence of post-varicocelectomy hydrocele. METHODS Consecutive patients treated for varicocele at our institution were evaluated for inclusion....

Introduction: We present a retrospective 2-year follow-up cohort of 103 men with testicular microlithiasis (TML) and discuss patient compliance and the value of surveillance. Methods: A retrospective analysis of patients examined with scrotal ultrasonography (US) in the period from 2008 through 2010 was performed. A total of 103 men with TML were diagnosed and offered US follow-up every 6 month...

be discussed prior to dispensation. At present, no standards exist on how to best manage this type of a situation clinically. It is advised that prior to initiation of TST, baseline reproductive function should be assessed. All men should be given the option of obtaining a semen analysis and serum FSH level before starting exogenous testosterone. Coupled with a focused genital examination and d...

This study was aimed to identify the changes in the fine structure of the testis following chronic administration of testoviron. Thirty male adult albino rats of Wistar strain were taken in control or untreated group and thirty rats in the treated group. The animals of this group were medicated with intramuscular injection of testoviron at a dose of 1.143mg / rat in the gluteal region. The body...

IN A STUDY comparing the antiatherogenic action of estradiol-17a and of estradiol-17/? in cholesterol-fed chickens, it was observed that, although both isomers were able to induce testicular atrophy at the dosage used, only estradiol-17/3 prevented coronary atherosclerosis j 1 2 similarly, in men active estrogens but not estradiol-17a are able to influence blood lipids. The mechanisms involved ...

Myotonic dystrophy 1 (DM1) is a multi-system disorder characterized by endocrine defects that include testicular and tubular atrophy, oligospermia, Leydig cell hyperproliferation and increased follicle stimulating hormone (FSH) levels. DM1 results from a CTG expansion that causes transcriptional silencing of the flanking SIX5 allele. Loss of Six5 results in male sterility and a progressive decr...

Objectives: This study was conducted to evaluate the histological findings from testicular biopsies in azoospermic men seen at the Lagos State University Teaching Hospital, Ikeja Lagos, Nigeria. Patients and Methods: A retrospective study of testicular biopsies of azoospermic men who presented to our institution from 2005 to 2006 was performed. The patient’s age, type of infertility and histopa...

Despite of many benefits of nanoparticles induced, their increasing usage raises concern about the consequences and health threats that it might bring to humans. So, the current study evaluated the testicular defects after i.p. injection of silver naoparticles (AgNPs). Male mice, weighing 31-34 g, and of 3 months old were randomly assigned into three groups with respect to concentration of nano...