During normal metabolic functions, highly reactive compounds called free radicals are generated in the body; however, they may also be introduced from the environment. These molecules are inherently unstable as they possess lone pair of electrons and hence become highly reactive. They react with cellular molecules such as proteins, lipids and carbohydrates, and denature them. As a result of thi...

BACKGROUND Dysmorphology and dysfunction caused by prenatal ethanol consumption in different organs of the offspring are wellknown phenomena. The objective of the present study was to explore the antioxidant effect of vitamin E supplementation on testis damage induced by maternal ethanol consumption during pregnancy and early postnatal days. METHODS Pregnant Wistar rats on gestation day 7 wer...

OBJECTIVES To describe the importance of the antioxidant enzymes superoxide dismutase, glutathione peroxidase, and catalase working together in human cells against toxic reactive oxygen species, their relationship with several pathophysiologic processes and their possible therapeutic implications. CONCLUSIONS Reactive oxygen species (ROS) are involved in the cell growth, differentiation, prog...

The interrelationship among water-stress-induced abscisic acid (ABA) accumulation, the generation of reactive oxygen species (ROS), and the activities of several antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), and glutathione reductase (GR) was investigated in leaves of detached maize (Zea mays L.) plants exposed to -0.7 MPa water stress induc...

Objective: Aim of this study was to evaluate the effect of Zingiber officinale in mitigating oxidative damage and reproductive toxicity in the testis, induced by chronic dichlorvos administration in male Wistar rats. Methods: Twenty-four adult male Wistar rats were divided into 4 groups of 6 rats in each group. Group I received olive oil (1 ml/kg bwt/day) and served as control group, while Grou...

background: diabetes is considered as one of the most common chronic disease. studies show that diabetes decreases the activity of antioxidant enzymes. the purpose of this study was to examine the effect of the alcoholic extract of juglans regia leave on brain antioxidant enzymes in streptozotocin-induced diabetic rats. materials and methods: in this study, adult male wistar rats (n=40, weight ...

Reproductive health problem is more common nowadays and various causes like nutritional defect, socio-economic problems, life style changes are reason for that, among those reason, one important factor is environmental factor. In this study, the pesticide, Lindane is used to induce reproductive toxicity and the levels of male reproductive hormone, antioxidant and histopathology of rat testis wa...

AIM Methyl-tertiary-butyl ether (MTBE), a well-known gasoline oxygenate compound, is still used in several countries. Several studies investigated the effects of MTBE on the activity of phase II metabolism enzymes. There is no published data on the effect(s) of short-term exposure to MTBE on mRNA levels of antioxidant genes. Therefore, the present study was carried out. METHODS A total of 15 ...

OBJECTIVES Cyclophosphamide (CP) toxicity on testis was hampered by squid ink polysaccharide (SIP) via restoration of antioxidant ability in our previous investigations. This study investigated roles of Nrf2/ARE signal pathway in testis of treated mice. MATERIALS AND METHODS Male Kunming mice were employed to undergo treatment with SIP and/or CP. Protein levels of Nrf2, keap-1, histone deacet...