Objective(s):Cyclophosphamide (CP) toxicity on testis was hampered by squid ink polysaccharide (SIP) via restoration of antioxidant ability in our previous investigations. This study investigated roles of Nrf2/ARE signal pathway in testis of treated mice. Materials and Methods: Male Kunming mice were employed to undergo treatment with SIP and/or CP. Protein levels of Nrf2, keap-1, histone deac...

background: busulfan (bus) is a chemotherapy drug that is widely used for cancer treatment. however, administration of busulfan may cause temporary or permanent sterility in male patients. therefore, reduction of this side is necessary. objective: evaluation of the protective effects of l-carnitine and testis homogenized tissue (tht) on sperm parameters and the testis structure after busulfan t...

Background and objectives: Cisplatin (CP), a highly effective antineoplastic drug, causes testicular damage. Zataria multiflora Boiss. (ZM), a medicinal plant, has antioxidant and anti-inflammatory properties. The aim of this study was to investigate the effects of ZM against cisplatin-induced testicular toxicity. Methods: Thirty-two adult male mice wer...

N-ethyl-N-nitrosourea (ENU), a well known alkylating agent, is a powerful mutagen in mouse spermatogonia that is frequently used to generate mutant mice for the study of gene function. The present study was performed to investigate the toxic effects of a suggested ENU treatment protocol (100 mg/kg ENU once a week for three consecutive weeks) on the C57BL/6J mouse testis using light and transmis...

Spermatic cord torsion happens rather frequently in young men. It must be discovered early on, to allow for the possibility of removal by surgery. It appears from recently written medical articles that the endocrine function of the testis is protected following several hours of torsion and the risk of immunological damage to the contralateral testis is subsequently reduced.

Aim: Our aim was to gain an idea about testicular injury by comparing the reduced volume, which is one of indirect indicators damage in undescended testes, and evaluating microvascular blood flow superb imaging, also determine whether imaging modes could detect more detail decreased volume testes. Material methods: We compared testes via conventional Doppler color monochrome techniques with con...

A determination of the absolute amounts of high-mobility-group proteins 1 and 2 (HMG1 and HMG2) in rat tissues demonstrated that amounts of HMG2 were low in non-proliferating tissues, somewhat higher in proliferating and lymphoid tissues, but were extremely elevated in the testis. This increase was due to a germ-cell-specific form of HMG2 with increased mobility relative to somatic HMG2 on acid...