نتایج جستجو برای: tetanus toxin
تعداد نتایج: 58433 فیلتر نتایج به سال:
The problem of new psychoactive substances is emerging globally. Cannabinoid receptors mediate the action of synthetic cannabinoids, which are one of most abused drugs. Recently, cannabinoid receptors 1 (CB1R) have been reported to silence glutamatergic nerve terminals in cerebellar granule cells via synaptic vesicle redistribution. This study aimed to determine whether synthetic cannabinoid ad...
BACKGROUND Tetanus is primarily a disease of the elderly. Both the incidence and the case-fatality rates are higher in the elderly population. Physicians need to be aware of special needs concerning the treatment of tetanus in this population. METHODS A comprehensive review of the literature concerning the treatment of tetanus was undertaken. Using the key words "tetanus," "geriatric," "elder...
A nonspecific binding of antibodies to diphtheria toxin, especially in adult serum samples, was observed in our diphtheria-tetanus-pertussis multiplex immunoassay (DTaP4 MIA). This can be significantly reduced by the use of diphtheria toxoid, achieving a good correlation with the Vero cell neutralization test and the toxin binding inhibition assay.
Bacillus anthracis, the causal agent of anthrax, synthesizes two surface layer (S-layer) proteins, EA1 and Sap, which account for 5 to 10% of total protein and are expressed in vivo. A recombinant B. anthracis strain was constructed by integrating into the chromosome a translational fusion harboring the DNA fragments encoding the cell wall-targeting domain of the S-layer protein EA1 and tetanus...
The problem of new psychoactive substances is emerging globally. Cannabinoid receptors mediate the action of synthetic cannabinoids, which are one of most abused drugs. Recently, cannabinoid receptors 1 (CB1R) have been reported to silence glutamatergic nerve terminals in cerebellar granule cells via synaptic vesicle redistribution. This study aimed to determine whether synthetic cannabinoid ad...
The problem of new psychoactive substances is emerging globally. Cannabinoid receptors mediate the action of synthetic cannabinoids, which are one of most abused drugs. Recently, cannabinoid receptors 1 (CB1R) have been reported to silence glutamatergic nerve terminals in cerebellar granule cells via synaptic vesicle redistribution. This study aimed to determine whether synthetic cannabinoid ad...
The problem of new psychoactive substances is emerging globally. Cannabinoid receptors mediate the action of synthetic cannabinoids, which are one of most abused drugs. Recently, cannabinoid receptors 1 (CB1R) have been reported to silence glutamatergic nerve terminals in cerebellar granule cells via synaptic vesicle redistribution. This study aimed to determine whether synthetic cannabinoid ad...
NaCl absorption by the thick ascending limb of Henle's loop (TAL) is mediated by the apical Na-K-2Cl cotransporter NKCC2. cAMP increases NaCl absorption in the TAL by stimulating NKCC2. In oocytes, cAMP increases NKCC2 activity by regulating its trafficking. However, the mechanism by which cAMP stimulates NKCC2 in TALs is not clear. We hypothesized that cAMP increases surface expression of NKCC...
Tetanus is caused by a neurotoxin produced by the gram-positive bacterium Clostridum tetani which forms spores. Tetanus begins when spores are introduced into damaged tissue. The toxin blocks inhibitory neurotransmitters in the central nervous system and causes the muscular stiffness and spasms typical of generalized tetanus. The disease may affect any age group, and case-fatality rates are hig...
Tetanus is a neurologic disorder caused by tetanospasmin, a protein toxin elaborated by Clostridium tetani. Cephalic tetanus is a localized form of the disease causing trismus and dysfunction of cranial nerves. We report the case of a man who presented with facial trauma, complete ophthalmoplegia, exophthalmos, areactive mydriasis, and periorbital hematoma. An orbital CT revealed air bubbles in...
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