BACKGROUND TRPV1 is a ligand-gated ion channel whose activation by capsaicin increases intracellular Ca(2+) ([Ca(2+)](i)). TRPV1 and cannabinoid CB(1) receptor activation are capable of eliciting analgesia. In this study, using recombinant human (h) and rat (r) TRPV1 receptors expressed in HEK293 cells, we have performed a comparison of both TRPV1 species at 22 and 37 degrees C and compared end...

Background: 15 patients diagnosed with autism spectrum disorder (ASD) from a neurodevelopment outpatient clinic in combined use of Cannabidiol (CBD) and Tetrahydrocannabinol (THC), 100 mg/ml CBD concentration 3 THC, initial dosage 1 mg/kg/day maximum 5 for six-month period. The were all non-syndromic, without epilepsy, ASD level 2 or 3, associated intellectual deficiency.