The posterior thalamic nucleus (PO) is a higher order nucleus heavily implicated in the processing of somatosensory information. We have previously shown in rodent models that activity in PO is tightly regulated by inhibitory inputs from a GABAergic nucleus known as the zona incerta (ZI). The level of incertal inhibition varies under both physiological and pathological conditions, leading to co...

A recent study has proved that unilateral deep brain stimulation (DBS) of the subthalamic nucleus has bilateral effects. However, it is still unclear whether unilateral ventral intermediate thalamic nucleus (Vim) DBS exerts exclusively contralateral or bilateral effects on tremor. Previous studies demonstrated a clinically irrelevant improvement on the nontarget side after thalamic stimulator i...

The evidence presented by Craig and his colleagues for an important projection from lamina I spinothalamic tract neurons to a renamed thalamic nucleus (the posterior part of the ventral medial nucleus or VMpo), as well as to the ventrocaudal medial dorsal and the ventral posterior inferior thalamic nuclei, is critically reviewed. Of particular concern is the denial of an important nociceptive l...

The evidence presented by Craig and his colleagues for an important projection from lamina I spinothalamic tract neurons to a renamed thalamic nucleus (the posterior part of the ventral medial nucleus or VMpo), as well as to the ventrocaudal medial dorsal and the ventral posterior inferior thalamic nuclei, is critically reviewed. Of particular concern is the denial of an important nociceptive l...

Presently, at least 60 million people are suffering from epilepsy worldwide. Although multiple pharmacological options for treatment exist, about 30% to 40% of these patients estimated have drug-resistant (DRE), which is associated with severe disability and morbidity. The surgical restricted either open procedures or laser ablations. When a resective option not favorable, then neuromodulation ...

The present study analyses the anatomical arrangement of the projections linking the Wistar rat parafascicular thalamic nucleus (PF) and basal ganglia structures, such as the striatum and the subthalamic nucleus (STN), by using neuroanatomical tract-tracing techniques. Both the thalamostriatal and the striato-entopeduncular projections were topographically organized, and several areas of overla...

BACKGROUND Spike-wave discharges, underlying absence seizures, are generated within a cortico-thalamo-cortical network that involves the somatosensory cortex, the reticular thalamic nucleus, and the ventrobasal thalamic nuclei. Activation of T-type voltage-sensitive calcium channels (VSCCs) contributes to the pathological oscillatory activity of this network, and some of the first-line drugs us...

The thalamus undergoes significant volume loss and microstructural change with increasing age. Alterations in thalamo-cortical connectivity may contribute to the decline in cognitive ability associated with aging. The aim of this study was to assess changes in thalamic shape and in the volume and diffusivity of thalamic regions parcellated by their connectivity to specific cortical regions in o...

The goal of this study was to establish a structural basis for thalamic and visceral integration. We sought to define neural networks that convey visceral or integrated environmental stimuli to the diffuse thalamocortical relay system and that link periodic changes in forebrain and visceral reflex function. Our experiments were designed to determine whether afferents to the midline-intralaminar...