A. 46-Way Sequence Conservation: variants within highly conserved regions are likely to have more impact than those within high variability regions; therefore we used two measures of evolutionary conservation, namely PhastCons (Siepel et al., 2005) and PhyloP (Pollard et al., 2010) scores, obtained from the multiple sequence alignment (at the nucleotide level) of 46 vertebrate genomes to the hu...