Using the 12-m APEX telescope, we have detected redshifted emission from the 157.74 μm [CII] line in the z = 4.4074 quasar BRI 1335-0417. The linewidth and redshift are in good agreement with previous observations of high-J CO line emission. We measure a [CII] line luminosity, L[CII] = (16.4 ± 2.6) × 109 L , making BRI 1335-0417 the most luminous, unlensed [CII] line emitter known at high-redsh...

A 17-year-old, nationally ranked, male tennis player (AH) had been experiencing heat cramps during tennis match play. His medical history and previous physical exams were unremarkable, and his in-office blood chemistry profiles were normal. On-court evaluation and an analysis of a 3-day dietary record revealed that AH's sweat rate was extensive (2.5 L.hr-1) and that his potential daily on-court...

Obstructive sleep apnea/hypopnea syndrome (OSA/HS) is the basis of the spectrum of sleep-disordered breathing (SDB) and is a condition characterized by the presence of snoring, repetitive partial upper airway obstruction (hypopnea) and/or intermittent complete obstruction (apnea), long enough to cause reduce the level of oxygen in the blood (desaturation), fragmented sleep and excessive daytime...

Acquired hemophilia (AH) is a rare disease with an estimated prevalence of 1.48 cases/million people/year and a mortality rate of 9-22%, according to data obtained in the United Kingdom in a hemophilia surveillance study [1]. Unlike congenital hemophilia, in which the presentation is exclusive to men, AH has no gender bias. It is characterized by the occurrence of spontaneous bleeding in differ...

Acquired haemophilia (AH) is a rare bleeding disorder characterized by the presence of acquired inhibitors against Factor VIII causing disruption of coagulation cascade. It has no known genetic inheritance, and diagnosis remains a challenge. The peculiar presentations are later age of onset as acute pain in weight-bearing joints and spontaneous muscle haematoma with isolated prolonged activated...

OBJECTIVE The effects of bazedoxifene (BZA)/conjugated estrogens (CE) on sleep and health-related quality of life (HRQoL) were evaluated in nonhysterectomized postmenopausal women who were enrolled in a randomized, double-blind, placebo- and active-controlled phase 3 trial. METHODS The sleep/HRQoL substudy enrolled 459 women with bothersome moderate to severe vasomotor symptoms who were rando...