The SARS-CoV-2 pandemic highlights the need for a detailed molecular understanding of protective antibody responses. This is underscored by emergence and spread variants, including Alpha (B.1.1.7) Delta (B.1.617.2), some which appear to be less effectively targeted current monoclonal antibodies vaccines. Here we report high resolution comprehensive map recognition spike receptor binding domain ...

Abstract T-cell receptor mimic antibodies (TCRm) have become an attractive therapeutic modality group as they allow for the targeting of intracellular proteins presented by HLA, which may a large potential new targets. However, polymorphic nature classical HLA class I and findings downregulation in cancer cells might limit use these agents treatment. An alternative approach would be to target p...