dopa responsive dystonia (drd) is a dystonic syndrome of childhood, usually affecting gait and subsequently developing into parkinsonism with a dramatic therapeutic response to levodopa. at the best of our recollection this is the first case in iranian medical literature of a 13 year old boy, affected by this interesting, rare and treatable disease which can be easily diagnosed if clinicians ha...

results there was a real faster response in the first group; while groups 3 and 4 had the slowest responses to treatment. rates of responsiveness seemed to have no significant difference between the groups, but side effects were significantly much frequent in the first group. conclusions intralesional triamcinolone acetonide with cryotherapy showed the most efficacies with more adverse effects,...

conclusions this study showed the importance of considering syndrome differentiation and temperaments in interpreting the effect of p. granatum peels extract on ulcerative colitis. results therapeutic response was significantly higher in patients with hot temperament compared to patients with cold temperament in the p. granatum group (1.916 ± 0.492 versus -0.500 ± 0.500, p = 0.029). methods sev...

metabolic syndrome and its pathological sequel, type 2 diabetes are considered as important global health problems. metformin is the most common drug prescribed for patients with this disorder. consequently, understanding the genetic pathways involved in pharmacokinetics and pharmacodynamics of this drug can have a considerable effect on the personalized treatment of type 2 diabetes. in this st...

background: proteolytic enzymes have an important role in variety of physiological and pathological functions. they have been used in therapeutic and pharmaceutical applications. characterizations of extracellular proteases from various strains of s. marcescens indicate that most strains produce a very similar major metalloprotease. this metalloprotease (serrapeptidase, serrapeptase) is an impo...